Plants have evolved a sophisticated innate immune system to defend against pathogen infection, and intracellular nucleotide-binding, leucine-rich repeat (NLR or NB-LRR) immune receptors are one of the main components of this system. NLR activity is fine-tuned by intra- and intermolecular interactions. We survey what is known about the conservation and diversity of NLR-interacting proteins, and divide them into seven major categories. We discuss the molecular mechanisms by which NLR activities are regulated and how understanding this regulation has potential to facilitate the engineering of NLRs for crop improvement.

中文翻译：

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微调抗扰度：植物NLR的播放器和调节器。

植物已经进化出一种先进的先天免疫系统来防御病原体感染，而细胞内核苷酸结合，富含亮氨酸的重复序列（NLR或NB-LRR）免疫受体是该系统的主要组成部分。NLR活性可通过分子内和分子间相互作用进行微调。我们调查了有关NLR相互作用蛋白的保守性和多样性的知识，并将其分为七个主要类别。我们讨论了调控NLR活性的分子机制，以及如何理解这种调控具有促进NLRs改良作物的潜力。