当前位置:
X-MOL 学术
›
Tetrahedron
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
New P-Chirogenic tert.-butyl-xantphos ligands and their application in asymmetric hydrogenation and alkylation
Tetrahedron ( IF 2.1 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.tet.2020.131142 Jens Holz , Gudrun Wenzel , Anke Spannenberg , Mark Gandelman , Armin Börner
中文翻译:
新的P-深绿叔胺。丁基-黄原磷配体及其在不对称氢化和烷基化中的应用
更新日期:2020-03-19
Tetrahedron ( IF 2.1 ) Pub Date : 2020-03-17 , DOI: 10.1016/j.tet.2020.131142 Jens Holz , Gudrun Wenzel , Anke Spannenberg , Mark Gandelman , Armin Börner
The synthesis of a broad library of new P-chirogenic Xantphos ligands is reported. A special feature is 2,7-di-tert.-butyl substituents in the backbone which requires the modification of the original synthetic approach. In comparison to related ligands reported formerly the substitution has a considerable influence on the results (yield and % e.e.) of metal catalyzed reactions, e.g. asymmetric rhodium catalyzed hydrogenation of isophorone and the palladium catalyzed alkylation, respectively.
中文翻译:
新的P-深绿叔胺。丁基-黄原磷配体及其在不对称氢化和烷基化中的应用
报道了合成新的P-手性Xantphos配体的广泛文库。比较特别的是2,7-二-叔-在需要原来的合成方法的变形例的主链丁基的取代基。与先前报道的相关配体相比,取代对金属催化反应的结果(产率和%ee)有很大影响,例如分别由不对称铑催化的异佛尔酮氢化和钯催化的烷基化。