Many persons with autism spectrum disorder (ASD) are treated in long-term specialised care. In this population, suicidal behaviour troubles patients, families, and specialists in the field because it is difficult to treat. At present, there is no documented effective therapy for suicidal behaviour in ASD (Autism Research 7:507-521, 2014; Crisis 35:301-309, 2014). Dialectical Behaviour Therapy (DBT) is an efficacious treatment programme for chronically suicidal and/or self-harm behaviour in patients with Borderline Personality Disorder (J Psychiatry 166:1365-1374, 2014; Linehan MM. Cognitive behavioural therapy of borderline personality disorder. 1993). This study will evaluate the efficacy of DBT in persons with ASD and suicidal/ self- destructive behaviour in a multicentre randomised controlled clinical trial. One hundred twenty-eight persons with autism and suicidal and/or self-harming behaviour will be recruited from specialised mental healthcare services and randomised into two conditions: 1) the DBT condition in which the participants have weekly individual cognitive behavioural therapy sessions and a 2.5 h skills training group session twice per week during 6 months, and 2) the treatment as usual condition which consists of weekly individual therapy sessions of 30–45 min with a psychotherapist or social worker. Assessments will take place at baseline, at post-treatment (6 months), and after a follow-up period of 12 months. The mediators will also be assessed at 3 months. The primary outcome is the level of suicidal ideation and behaviour. The secondary outcomes are anxiety and social performance, depression, core symptoms of ASD, quality of life, and cost-utility. Emotion regulation and therapeutic alliance are hypothesised to mediate the effects on the primary outcome. The results from this study will provide an evaluation of the efficacy of DBT treatment in persons with ASD on suicidal and self-harming behaviour. The study is conducted in routine mental health services which enhances the generalisability of the study results to clinical practice. ISRCTN96632579. Registered 1 May 2019. Retrospectively registered.

中文翻译：

---

孤独症患者具有自杀和/或自我毁灭行为（DIASS）的辩证行为疗法的效果：一项多中心随机对照试验的研究方案。

许多患有自闭症谱系障碍（ASD）的人都接受了长期的专门护理。在这一人群中，自杀行为困扰着该领域的患者，家庭和专家，因为难以治疗。目前，尚无关于ASD自杀行为的有效疗法的文献报道（Autism Research 7：507-521，2014; Crisis 35：301-309，2014）。辩证行为疗法（DBT）是一种治疗边缘人格障碍患者的长期自杀和/或自残行为的有效治疗方案（J Psychiatry 166：1365-1374，2014; Linehan MM。边缘人格障碍的认知行为疗法.1993） ）。这项研究将在一项多中心随机对照临床试验中评估DBT对ASD和自杀/自毁行为患者的疗效。将从专门的精神保健服务机构招募128名患有自闭症，自杀和/或自残行为的人，并将其随机分为以下两种情况：1）DBT条件，即参与者每周进行一次单独的认知行为治疗； 2.5 h技能训练小组在6个月内每周两次会议，以及2）正常情况下的治疗，包括每周一次与心理治疗师或社会工作者进行30-45分钟的单独治疗。评估将在基线，治疗后（6个月）以及12个月的随访期后进行。调解员还将在3个月时接受评估。主要结果是自杀意念和行为水平。次要结果是焦虑和社交表现，抑郁，自闭症的核心症状，生活质量，和成本效用。假设情绪调节和治疗联盟可以介导对主要结局的影响。这项研究的结果将评估DBT治疗ASD患者自杀和自残行为的功效。这项研究是在常规的心理健康服务中进行的，从而提高了研究结果对临床实践的普遍性。ISRCTN96632579。注册于2019年5月1日。这项研究是在常规的心理健康服务中进行的，从而提高了研究结果对临床实践的普遍性。ISRCTN96632579。注册于2019年5月1日。这项研究是在常规的心理健康服务中进行的，从而提高了研究结果对临床实践的普遍性。ISRCTN96632579。注册于2019年5月1日。