To measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis. In total 45 eyes from 45 subjects, who underwent FS-LASIK during June 2017 to December 2017 in Guangdong Provincial People’s Hospital, were recruited in this study. Vessel density in macula and optic nerve head were measured by optical coherence tomography angiography before and after transient elevation in intraocular pressure caused by application of suction ring during surgery. Vessel density (VD) at superficial (SCP) plexus of macular region did not differ after surgery (F(3,132) = 1.41, P = 0.24), while the deep (DCP) plexus of macular region significantly decreased 1 day after surgery (P = 0.001) but returned to its baseline value 1 month postoperatively (P = 0.1). Vessel density of optic nerve head region had no significant changes after surgery (F(2.51,95.18) = 0.6, P = 0.59). A short-term temporary decrease of vessel density at deep layer of macular region was observed in eyes undergoing FS-LASIK. However, the retinal capillary density went back to preoperative level 1 month after surgery. Therefore, transient IOP spike during FS-LASIK did not cause long-term decline of retinal microcirculation.

中文翻译：

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飞秒激光辅助LASIK术后黄斑和视神经乳头的微血管变化：光学相干断层扫描血管造影研究

飞秒激光辅助激光原位角膜磨镶术前后测量黄斑和视神经头的微循环变化。该研究共纳入了2017年6月至2017年12月在广东省人民医院接受FS-LASIK手术的45位受试者的45只眼睛。在手术过程中由于应用吸引环而引起的眼压暂时升高之前和之后，通过光学相干断层扫描血管造影术测量了黄斑和视神经乳头中的血管密度。术后1天，黄斑区浅层（SCP）丛的血管密度（VD）不变（F（3,132）= 1.41，P = 0.24），而术后1天黄斑区深（DCP）丛明显降低（P = 0.001），但术后1个月恢复到基线值（P = 0.1）。术后视神经头部区域的血管密度无明显变化（F（2.51,95.18）= 0.6，P = 0.59）。在接受FS-LASIK手术的眼睛中，观察到黄斑区深层血管密度的短期暂时降低。但是，术后1个月，视网膜毛细血管密度恢复到术前水平。因此，FS-LASIK手术中短暂的IOP峰值不会导致视网膜微循环的长期下降。