The burden of disease due to cancer remains substantial. Since the value of real-world evidence has also been recognised by regulatory agencies, we established a Research Ethics Committee (REC) approved research database for cancer patients (Reference: 18/NW/0297). Guy’s Cancer Cohort introduces the concept of opt-out consent processes for research in a subset of oncology patients diagnosed and treated at a large NHS Trust in the UK. From April 2016 until March 2017, 1388 eligible patients visited Guy’s and St Thomas’ NHS Foundation Trust (GSTT) for breast cancer management. For urological cancers this number was 1757 and for lung cancer 677. The Cohort consists of a large repository of routinely collected clinical data recorded both retrospectively and prospectively. The database contains detailed clinical information collected at various timepoints across the treatment pathway inclusive of diagnostic data, and data on disease progression, recurrence and survival. Guy’s Cancer Cohort provides a valuable infrastructure to answer a wide variety of research questions of a clinical, mechanistic, and supportive care nature. Clinical research using this database will result in improved patient safety and experience. Guy’s Cancer Cohort promotes collaborative research and will accept applications for the release of anonymised datasets for research purposes.

中文翻译：

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盖伊的癌症队列–癌症路径的现实证据

由于癌症引起的疾病负担仍然很大。由于现实世界证据的价值也得到了监管机构的认可，因此我们建立了经研究伦理委员会（REC）批准的癌症患者研究数据库（参考：18 / NW / 0297）。盖伊癌症研究小组引入了选择退出同意程序的概念，用于在英国一家大型NHS信托基金中诊断和治疗的部分肿瘤患者的研究。从2016年4月到2017年3月，有1388名合格患者访问了盖伊和圣托马斯NHS基金会信托基金（GSTT）进行乳腺癌治疗。对于泌尿系统癌症，该数字为1757，对于肺癌为677。该队列由常规和回顾性记录的常规收集的大量临床数据组成。该数据库包含在整个治疗途径中各个时间点收集的详细临床信息，包括诊断数据以及有关疾病进展，复发和生存的数据。盖伊癌症研究小组提供了宝贵的基础设施，可以回答各种临床，机械和支持治疗性质的研究问题。使用该数据库的临床研究将改善患者的安全性和经验。Guy's Cancer Cohort促进协作研究，并将接受出于研究目的发布匿名数据集的申请。和支持护理性质。使用该数据库的临床研究将改善患者的安全性和经验。Guy's Cancer Cohort促进协作研究，并将接受出于研究目的发布匿名数据集的申请。和支持护理性质。使用该数据库的临床研究将改善患者的安全性和经验。Guy's Cancer Cohort促进协作研究，并将接受出于研究目的发布匿名数据集的申请。