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Ellagitannins Inhibit the Exsheathment of Haemonchus contortus and Trichostrongylus colubriformis Larvae: The Efficiency Increases Together with the Molecular Size
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-03-26 , DOI: 10.1021/acs.jafc.9b06774 Maarit Karonen 1 , Jeffrey R. Ahern 1 , Lucie Legroux 2 , Jussi Suvanto 1 , Marica T. Engström 1 , Jari Sinkkonen 1 , Juha-Pekka Salminen 1 , Hervé Hoste 2
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-03-26 , DOI: 10.1021/acs.jafc.9b06774 Maarit Karonen 1 , Jeffrey R. Ahern 1 , Lucie Legroux 2 , Jussi Suvanto 1 , Marica T. Engström 1 , Jari Sinkkonen 1 , Juha-Pekka Salminen 1 , Hervé Hoste 2
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Worldwide, parasitic gastrointestinal nematodes continue to threaten animal health, welfare, and production in outdoor breeding systems of small ruminants. For more than 50 years, the control of these parasitic worms has relied on the use of commercial synthetic anthelmintics. However, anthelmintic resistance in worm populations is nowadays widespread and requires novel solutions. The use of tannin-rich plants has been suggested as an alternative to synthetic anthelmintics to control gastrointestinal nematodes. The majority of previous studies have focused on the activity of proanthocyanidins (syn condensed tannins), and less is known about ellagitannins. In this study, the effects of 30 structurally unique ellagitannins on the exsheathment of third-stage infective larvae were examined on Haemonchus contortus and Trichostrongylus colubriformis by the in vitro larval exsheathment inhibition assay. Ellagitannins were found to be promising natural anthelmintics as they showed direct inhibition on larval exsheathment for both nematode species. In general, ellagitannins were more efficient at inhibiting the exsheathment of H. contortus larvae than those of T. colubriformis. The efficiency of inhibition increased as the degree of oligomerization or the molecular weight of the ellagitannin increased. Otherwise, we found no other structural features of ellagitannins that significantly affected the anthelmintic activity on the third-stage infective larvae. The effective concentrations were physiologically relevant and should be achievable in the gastrointestinal tract also in in vivo conditions.
中文翻译：
Ellagitannins抑制捻转Haemonchus contortus和Trichostrongylus colubriformis幼虫：效率增加与分子大小。
在世界范围内，寄生性胃肠线虫继续威胁动物健康，福利以及小型反刍动物的室外繁殖系统中的生产。50多年来，对这些寄生虫的控制一直依赖于商业合成驱虫药的使用。但是，如今蠕虫种群中的驱虫抗药性很普遍，需要新颖的解决方案。已提出使用富含单宁的植物作为合成驱虫药的替代品，以控制胃肠道线虫。以前的大多数研究都集中在原花色素（合成缩合单宁）的活性上，而关于鞣花单宁的了解较少。在这项研究中，检查对30和结构独特的鞣花单宁在第三阶段的感染期幼虫的exsheathment影响捻转血矛线虫通过体外幼虫外皮抑制试验测定了钩端螺旋体和粘膜毛滴虫。鞣花单宁被认为是有前途的天然驱虫药，因为它们对两种线虫均显示出对幼虫剥皮的直接抑制作用。总的来说，鞣花单宁在抑制捻转血吸虫幼虫方面比colubriformis的更有效。。抑制效率随着寡聚度或鞣花单宁的分子量增加而增加。否则，我们没有发现鞣花单宁的其他结构特征会显着影响对第三阶段感染性幼虫的驱虫活性。有效浓度与生理有关，在体内条件下也应在胃肠道中可达到。
更新日期：2020-03-27
中文翻译：
Ellagitannins抑制捻转Haemonchus contortus和Trichostrongylus colubriformis幼虫：效率增加与分子大小。
在世界范围内，寄生性胃肠线虫继续威胁动物健康，福利以及小型反刍动物的室外繁殖系统中的生产。50多年来，对这些寄生虫的控制一直依赖于商业合成驱虫药的使用。但是，如今蠕虫种群中的驱虫抗药性很普遍，需要新颖的解决方案。已提出使用富含单宁的植物作为合成驱虫药的替代品，以控制胃肠道线虫。以前的大多数研究都集中在原花色素（合成缩合单宁）的活性上，而关于鞣花单宁的了解较少。在这项研究中，检查对30和结构独特的鞣花单宁在第三阶段的感染期幼虫的exsheathment影响捻转血矛线虫通过体外幼虫外皮抑制试验测定了钩端螺旋体和粘膜毛滴虫。鞣花单宁被认为是有前途的天然驱虫药，因为它们对两种线虫均显示出对幼虫剥皮的直接抑制作用。总的来说，鞣花单宁在抑制捻转血吸虫幼虫方面比colubriformis的更有效。。抑制效率随着寡聚度或鞣花单宁的分子量增加而增加。否则，我们没有发现鞣花单宁的其他结构特征会显着影响对第三阶段感染性幼虫的驱虫活性。有效浓度与生理有关，在体内条件下也应在胃肠道中可达到。
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