Moldable Crystalline α-Chitin Hydrogel with Toughness and Transparency toward Ocular Applications,ACS Applied Polymer Materials

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Moldable Crystalline α-Chitin Hydrogel with Toughness and Transparency toward Ocular Applications
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-03-17 , DOI: 10.1021/acsapm.0c00087
Noriyuki Isobe ₁ , Mikiko Tsudome ₁ , Ryosuke Kusumi ₂ , Masahisa Wada _{2,

3} , Katsuyuki Uematsu ₄ , Satoshi Okada ₁ , Shigeru Deguchi ₁

Affiliation

A N-acetylated chitosan hydrogel was investigated for ocular applications. One of the drawbacks in the original hydrogel protocol, poor moldability, was circumvented by optimizing the addition of the acetylating agent, acetic acid anhydride (Ac₂O), at −10 °C. This simple but significant optimization realized the preparation of N-acetylated chitosan hydrogels with a wider variety of parameters such as higher chitosan concentration and molecular weight, the use of a more benign solvent (ethanol replaced methanol), and the arbitral shapes ranging from microbeads and contact lenses to bulky blocks that could be gripped. The prepared N-acetylated chitosan hydrogels exhibited high transparency and integrity given the nanofibrous network made of highly crystalline α-chitin. Furthermore, the gel retained a regenerable character: an oven-dried gel was reswollen by emersion in an acid bath. These previously unnoticed advantages and the innate high biocompatibility of chitosan and chitin elevate N-acetylated chitosan hydrogel as a next-generation bio-derived soft material for ocular applications such as contact lenses, artificial corneas, and drug delivery vehicles.

中文翻译：

具有韧性和对眼用透明性的可成型结晶α-甲壳质水凝胶

研究了N-乙酰化的壳聚糖水凝胶在眼部的应用。通过在-10°C下优化乙酰化剂乙酸酐（Ac ₂ O）的添加，可以避免原始水凝胶规程的缺点之一，即可模塑性差。这种简单但重要的优化方法实现了N-乙酰化壳聚糖水凝胶的制备，该凝胶具有多种参数，例如较高的壳聚糖浓度和分子量，使用更温和的溶剂（乙醇替代甲醇）以及任意形状的微珠和隐形眼镜到可能被抓住的笨重块。准备好的N鉴于由高度结晶的α-甲壳素制成的纳米纤维网络，乙酰化的壳聚糖水凝胶具有较高的透明度和完整性。此外，该凝胶保留了可再生的特性：烤箱干燥的凝胶在酸浴中因浸没而溶胀。这些先前未被发现的优势以及壳聚糖和几丁质的先天高生物相容性提高了N-乙酰化壳聚糖水凝胶，作为下一代生物衍生的用于眼科应用的软材料，例如隐形眼镜，人造角膜和药物递送载体。

更新日期：2020-04-23

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