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Superhydrophobic Surfaces as a Source of Airborne Singlet Oxygen through Free Space for Photodynamic Therapy
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-03-17 , DOI: 10.1021/acsabm.0c00114
David Aebisher 1 , Dorota Bartusik-Aebisher 1 , Sarah J Belh 2, 3 , Goutam Ghosh 2, 3 , Andrés M Durantini 2, 4 , Yang Liu 3, 5 , QianFeng Xu 5 , Alan M Lyons 3, 5 , Alexander Greer 2, 3
Affiliation  

A superhydrophobic (SH) sandwich system has been developed to enable “contact-free” airborne singlet oxygen (1O2) delivery to a water droplet. The contact-free feature means that the sensitizer is physically separated from the droplet, which presents opportunities for photodynamic therapy (PDT). Trapping of airborne 1O2 in a H2O droplet residing on a lower SH surface was monitored with 9,10-anthracene dipropionate dianion by varying distances to an upper 1O2-generating surface. Short distances of 20 μm efficiently delivered airborne 1O2 to the droplet in single-digit picomolar steady-state concentrations. Delivery decreases linearly with distance, but 50% of the 1O2 steady-state concentration is trapped at a distance of 300 μm from the generating surface. The 1270 nm luminescence intensity was measured within the SH sandwich system, confirming the presence of airborne 1O2. Physical quenching of 1O2 to ground-state 3O2 by the water droplet itself and both physical and chemical quenching of 1O2 by the water droplet containing the trap 9,10-anthracene dipropionate dianion are observed. Unlike a majority of work in the field of PDT with dissolved sensitizers, where 1O2 diffuses short (hundreds of nanometers) distances, we show the delivery of airborne 1O2 via a superhydrophobic surface is effective through air in tenths of millimeters distances to oxidize an organic compound in water. Our results provide not only potential relevance to PDT but also surface bacterial inactivation processes.

中文翻译:

超疏水表面作为空气中单线态氧的来源,通过自由空间进行光动力治疗

已经开发了一种超疏水 (SH) 夹层系统,以实现“无接触”空气传播的单线态氧 ( 1 O 2 ) 输送到水滴。非接触特性意味着敏化剂与液滴物理分离,这为光动力疗法 (PDT) 提供了机会。使用 9,10-蒽二丙酸二价阴离子通过改变与上1 O 2产生表面的距离来监测位于下 SH 表面上的 H 2 O 液滴中空气中1 O 2的捕获。20 μm 的短距离有效输送空中1 O 2到单位数皮摩尔稳态浓度的液滴。输送随距离线性下降,但1 O 2稳态浓度的 50% 被捕获在距生成表面 300 μm 的距离处。在 SH 夹层系统内测量了 1270 nm 的发光强度,证实了空气中1 O 2的存在。通过水滴本身将1 O 2物理猝灭为基态3 O 2以及1 O 2的物理和化学猝灭通过含有捕集器的水滴观察到 9,10-蒽二丙酸二价阴离子。与溶解敏化剂的 PDT 领域中的大多数工作不同,其中1 O 2扩散短(数百纳米)距离,我们表明通过超疏水表面传递空气中的1 O 2在十分之一毫米距离内的空气中是有效的在水中氧化有机化合物。我们的结果不仅提供了与 PDT 的潜在相关性,而且还提供了表面细菌灭活过程。
更新日期:2020-04-23
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