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Prostate cancer risk in patients with melanoma: A systematic review and meta-analysis.
Cancer Medicine ( IF 2.9 ) Pub Date : 2020-03-16 , DOI: 10.1002/cam4.2995
Prakash Acharya 1 , Mahesh Mathur 1
Affiliation  

BACKGROUND The risk of prostate cancer in melanoma patients has been frequently assessed. However, a comprehensive meta-analysis specifically examining this association is lacking. Our aim was to quantify the risk of prostate cancer in melanoma patients based on the available evidence. METHODS A systematic review of the existing literature was performed in PubMed, Scopus, and Cochrane databases by two authors independently. Studies reporting the effect size in the form of standardized incidence ratio (SIR) were used for quantitative analyses. RESULTS Of 17 studies included in the review, a total of 15 studies with 282 592 male melanoma patients were used for the analysis. Random-effects meta-analysis found a 24% increased risk (SIR = 1.24, 95% confidence interval 1.18 to 1.30) of prostate cancer in melanoma patients compared to the general population, with a prediction interval of 1.05 to 1.45. The risk was consistently significant for various geographical regions and latitude. Heterogeneity was significant (I2 = 75%). CONCLUSION These results suggest that the incidence of prostate cancer is significantly higher in patients with melanoma compared to the general population.

中文翻译:

黑色素瘤患者的前列腺癌风险:系统评价和荟萃分析。

背景 经常评估黑色素瘤患者患前列腺癌的风险。然而,缺乏专门研究这种关联的综合荟萃分析。我们的目标是根据现有证据量化黑色素瘤患者患前列腺癌的风险。方法 由两位作者独立对 PubMed、Scopus 和 Cochrane 数据库中的现有文献进行系统评价。以标准化发病率 (SIR) 形式报告效应大小的研究用于定量分析。结果 该评价纳入的 17 项研究中,共有 15 项研究用于分析,共 282 592 名男性黑色素瘤患者。随机效应荟萃分析发现风险增加了 24%(SIR = 1.24,95% 置信区间为 1.18 到 1。30) 黑色素瘤患者前列腺癌的发生率与普通人群相比,预测区间为 1.05 至 1.45。对于不同的地理区域和纬度,风险始终显着。异质性显着(I2 = 75%)。结论 这些结果表明,与一般人群相比,黑色素瘤患者的前列腺癌发病率显着更高。
更新日期:2020-03-16
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