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Alpha-lipoic acid downregulates TRPV1 receptor via NF-κB and attenuates neuropathic pain in rats with diabetes.
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-03-16 , DOI: 10.1111/cns.13303
Bing-Yu Zhang 1 , Yi-Lian Zhang 1 , Qian Sun 2 , Ping-An Zhang 2 , Xi-Xi Wang 1 , Guang-Yin Xu 2 , Ji Hu 1 , Hong-Hong Zhang 1
Affiliation  

Painful diabetic neuropathy (PDN) is a refractory complication of diabetes. The study aimed to investigate the role of α‐lipoic acid (ALA) on the regulation of transient receptor potential vanilloid‐1 (TRPV1) in dorsal root ganglion (DRG) neurons of rats with diabetes.

中文翻译:

α-硫辛酸通过 NF-κB 下调 TRPV1 受体并减轻糖尿病大鼠的神经性疼痛。

疼痛性糖尿病神经病变(PDN)是糖尿病的难治性并发症。本研究旨在探讨α-硫辛酸(ALA)对糖尿病大鼠背根神经节(DRG)神经元瞬时受体电位香草素-1(TRPV1)的调节作用。
更新日期:2020-03-16
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