An evolutionary framework for treating pediatric sarcomas.,Cancer

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An evolutionary framework for treating pediatric sarcomas.
Cancer ( IF 6.1 ) Pub Date : 2020-03-16 , DOI: 10.1002/cncr.32777
Damon R Reed _{1,

2,

3} , Jonathan Metts ₄ , Mariyah Pressley _{2,

5} , Brooke L Fridley _{2,

6} , Masanori Hayashi ₇ , Michael S Isakoff ₈ , David M Loeb ₉ , Rikesh Makanji ₁₀ , Ryan D Roberts ₁₁ , Matteo Trucco ₁₂ , Lars M Wagner ₁₃ , Mark G Alexandrow ₂ , Robert A Gatenby _{2,

5,

10} , Joel S Brown _{2,

5}

Affiliation

Department of Interdisciplinary Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Adolescent and Young Adult Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St Petersburg, Florida.
Integrative Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Biostatistics and Bioinformatics Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Center for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, Connecticut.
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Department of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, Ohio.
Depatment of Pediatrics, University of Miami, Miami, Florida.
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.

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