The current review summarizes the latest achievements in the synthesis of piperidine-2,4-dione-type azaheterocycles. Two main groups traditional (carbonyl compound transformations) and novel (anionic enolate rearrangements) of complementary methods for the simple and effective preparation of structurally diverse compounds in racemic and enantiopure forms have been reported. Due to the specific structure and appropriate reactivity profiles of dione-type molecules, they are a convenient modern platform for the construction of functionalized piperidine-type systems possessing high synthetic and medicinal potential. This potential is successfully realized by the creation of highly active pharmaceutically relevant compounds and the synthesis of natural products.

中文翻译：

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哌啶-2,4-二酮型氮杂杂环的构建及其在现代药物开发和天然产物合成中的应用。

本综述总结了合成哌啶-2,4-二酮型氮杂杂环的最新进展。已经报道了两种主要的传统方法（羰基化合物转化）和新型方法（阴离子烯酸酯重排）的互补方法，这些方法可简单有效地制备外消旋和对映纯形式的结构多样的化合物。由于二酮型分子的特定结构和适当的反应性，它们是构建具有高合成和药用潜力的功能化哌啶型体系的便捷现代平台。通过创建高活性的药物相关化合物和合成天然产物，可以成功实现这一潜力。