Abstract

The crucial components governing individual powder property and functionality of microparticles were systematically investigated for the co-encapsulation of vitamin E (VE) with coenzyme Q₁₀ (CoQ₁₀). Whey protein isolate (WPI), WPI/soluble corn fiber (SCF), and WPI/maltodextrin were used as wall materials, to encapsulate composite VE/CoQ₁₀, sole VE, and sole CoQ₁₀. Nine types of microparticles were produced by a monodisperse-droplet spray dryer, to explicitly correlate each quality attribute to microparticle composition. All microparticles showed a high retention of core material (89.6–97.4%) and antioxidant activity, with distinctly different particle morphology, powder property, digestibility, and stability. The composition of wall material governed the majority of powder properties, whereas the bioactive core material affected storage stability, and impacted on particle morphology and powder color despite a low loading at 7% of total solids. The wall material that gave excellent powder properties did not always exhibit good functionality. WPI/SCF emulsion showed low viscosities of 7.51–11.71 cP, and the spray-dried microparticles showed spherical shape with excellent flowability (Carr’s index of 17.38%) and wettability (24 s); however, their stability during in vitro gastric digestion and storage trial was poor. The WPI/maltodextrin microparticles with distorted particle shape possibly experienced different particle formation processes from WPI/SCF, with improved stability on color, encapsulation efficiency, and antioxidant activity during storage for 35 days. The retention of VE and CoQ₁₀ after digestion for 60 min was 79% and 82%, respectively. The reported relationships between individual component and the property and functionality of microparticles would be useful for fabricating bioactive microparticles with precisely controlled quality.

中文翻译：

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壁和核心材料的相互作用对维生素E与辅酶Q 10共包封的微粒的性能和功能的影响

摘要

对于维生素E（VE）与辅酶Q ₁₀（CoQ ₁₀）的共包封，系统地研究了控制单个粉末性质和微粒功能的关键成分。乳清蛋白分离物（WPI），WPI /可溶性玉米纤维（SCF）和WPI /麦芽糊精被用作壁材，以包裹复合VE / CoQ ₁₀，唯一VE和唯一CoQ ₁₀。通过单分散液滴喷雾干燥器生产了九种类型的微粒，以明确地将每个质量属性与微粒组成相关联。所有微粒均显示出核心材料的高度保留（89.6–97.4％）和抗氧化活性，并且颗粒形态，粉末性质，消化率和稳定性也明显不同。壁材料的组成决定了粉末的大部分性能，而生物活性核心材料影响了储存稳定性，并且尽管在总固含量为7％的情况下负荷较低，但仍影响颗粒的形态和粉末颜色。具有出色粉末性能的墙面材料并不总是具有良好的功能性。WPI / SCF乳液的粘度低至7.51-11.71 cP，喷雾干燥的微粒呈球形，流动性极佳（卡尔指数为17。38％）和润湿性（24 s）；然而，它们在体外胃消化和储存试验中的稳定性很差。具有扭曲形状的WPI /麦芽糖糊精微粒可能经历了与WPI / SCF不同的颗粒形成过程，在存储35天期间，颜色稳定性，包封效率和抗氧化活性得到了改善。VE和CoQ的保留消化60分钟后的₁₀分别为79％和82％。所报告的单个组分与微粒的性质和功能之间的关系对于制造具有精确控制质量的生物活性微粒将是有用的。