Abstract

Purpose

To assess the dynamic of various health-related quality of life (HRQoL) parameters 3 years after pulmonary thromboendarterectomy (PTE), and to identify factors affecting HRQoL parameters in patients with chronic thromboembolic pulmonary hypertension (CTEPH) in the long-term follow-up after surgery.

Methods

This prospective cohort study included 128 patients with CTEPH before and after the PTE (3 year follow-up). The HRQoL was examined using the Short-Form 36 Health Survey Questionnaire (SF-36).

Results

In patients with CTEPH 3 years after PTE, a significant improvement in all the HRQoL parameters. The summary indicators of the physical and mental components of health remained at the same level as 1 year after the PTE and did not exceed 50 points. The residual pulmonary hypertension was a leading factor limiting parameters of physical and mental health 3 years after a PTE. In addition, the parameters of physical activity were adversely affected by age and the age-adjusted Charlson Comorbidity Index.

Conclusions

In the study group of patients with CTEPH, PTE contributes to a significant improvement in all HRQoL parameters, which observed both 1 year and 3 years after surgery. The leading factor adversely affecting the physical and emotional components of health in the long-term period after PTE was residual pulmonary hypertension recorded in the early postoperative period. In addition, some physical HRQoL parameters are affected by age and age-adjusted Charlson Comorbidity Index.

中文翻译：

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慢性血栓栓塞性肺动脉高压患者术后长期健康相关的生活质量。

摘要

目的

评估长期血栓栓塞性肺动脉高压（CTEPH）患者在进行肺血栓内膜切除术（PTE）3年后各种健康相关生活质量（HRQoL）参数的动态，并确定影响HRQoL参数的因素手术后。

方法

这项前瞻性队列研究纳入了PTE前后（三年随访）的128例CTEPH患者。使用简短的36型健康调查问卷（SF-36）对HRQoL进行了检查。

结果

在PTE后3年的CTEPH患者中，所有HRQoL参数都得到了显着改善。健康的身体和精神组成部分的汇总指标保持在PTE一年后的水平，并且不超过50分。残余肺动脉高压是限制PTE治疗3年后身心健康的主要因素。此外，体育活动的参数受到年龄和经年龄调整的查尔森合并症指数的不利影响。

结论

在CTEPH患者研究组中，PTE有助于所有HRQoL参数的显着改善，这些参数在手术后1年和3年都可观察到。在PTE术后长期内，对健康的身体和情感成分产生不利影响的主要因素是术后早期记录的残余肺动脉高压。此外，某些身体HRQoL参数会受到年龄和经年龄调整的查尔森合并症指数的影响。