Idiopathic pulmonary fibrosis (IPF) is an agnogenic, rare, and lethal disease, with high mortality and poor prognosis and a median survival time as short as 3 to 5 years after diagnosis. No effective therapeutic drugs are still not available not only in clinical practice, but also in preclinical phases. To better and deeper understand pulmonary fibrosis will provide more effective strategies for therapy. Mounting evidence suggests that noncoding RNAs (ncRNAs) and their interactions may contribute to lung fibrosis; however, the mechanisms underlying their roles are largely unknown. In this review, we systematically summarized the recent advances regarding the crucial roles of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) and crosstalk among them in the development of IPF. The perspective for related genes was well highlighted. In summary, ncRNA and their interactions play a key regulatory part in the progression of IPF and are bound to provide us with new diagnostic and therapeutic targets.

中文翻译：

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解密IPF进展中非编码RNA的串扰。

特发性肺纤维化（IPF）是一种致盲性，罕见和致死性疾病，死亡率高，预后差，诊断后中位生存时间短至3-5年。不仅在临床实践中，而且在临床前阶段，仍然没有有效的治疗药物。为了更好和更深入地了解肺纤维化将提供更有效的治疗策略。越来越多的证据表明，非编码RNA（ncRNA）及其相互作用可能导致肺纤维化。但是，其作用的基本机制尚不清楚。在这篇综述中，我们系统地总结了有关长的非编码RNA（lncRNA），microRNA（miRNA）和环形RNA（circRNA）的关键作用以及在IPF发展中它们之间的串扰的最新进展。相关基因的观点得到了很好的强调。总之，ncRNA及其相互作用在IPF的发展中起着关键的调节作用，必将为我们提供新的诊断和治疗靶标。