Abstract

The work was intended to develop a novel acrylic acid grafted hydrogel by chemical crosslinking of xanthan gum and starch under microwave irradiation. The swelling capacity of hydrogel was found to be dependent upon pH. The maximum swelling capacity of hydrogel was recorded as 32.21 g/g under the optimized conditions. The swelling capacity of hydrogel was quite higher than most of the hydrogels containing xanthan gum mentioned in the literature. Various characterization techniques including FTIR, SEM, TGA and XRD confirmed successful synthesis of hydrogel with porous morphology and better thermal stability. Synthesized hydrogel was employed as an oral drug delivery vehicle. Releasing behavior of the hydrogels for the drugs aspirin and paracetamol was studied under specific physiological conditions. The drug release was significantly higher at pH 7.4 in comparison to acidic and neutral media. Synthesized hydrogel was found to be suitable for colon-specific drug delivery. Both aspirin and paracetamol followed non-Fickian diffusion mechanism at higher pH and Fickian mechanism at lower pH. Release profiles of both the drugs were best fitted in the first order model. Hydrogel was found to be non-cytotoxic to human fibroblast cells and biocompatible, with a low hemolytic ratio. Consequently results supported potential of this non-toxic, biofriendly and appropriately tailored polysaccharide based hydrogel to be used as drug delivery carrier for controlled and site-specific drug release.

Graphic abstract

中文翻译：

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交联的黄原胶-淀粉水凝胶是可控药物输送的有前途的材料

摘要

该工作旨在通过在微波辐射下通过黄原胶和淀粉的化学交联来开发新型的丙烯酸接枝水凝胶。发现水凝胶的溶胀能力取决于pH。在最佳条件下，水凝胶的最大溶胀能力记录为32.21 g / g。水凝胶的溶胀能力比文献中提到的大多数含黄原胶的水凝胶要高得多。包括FTIR，SEM，TGA和XRD在内的各种表征技术证实成功合成了具有多孔形态和更好的热稳定性的水凝胶。合成的水凝胶用作口服药物递送载体。在特定的生理条件下，研究了水凝胶对阿司匹林和对乙酰氨基酚的释放行为。在pH 7时药物释放明显更高。4与酸性和中性介质相比。发现合成的水凝胶适用于结肠特异性药物递送。阿司匹林和扑热息痛在较高pH值时均遵循非菲克扩散机制，在较低pH值时均遵循非菲克扩散机制。两种药物的释放曲线最适合一级模型。发现水凝胶对人成纤维细胞无细胞毒性，具有生物相容性，溶血率低。因此，结果支持了这种无毒，生物友好和经过适当调整的基于多糖的水凝胶的潜力，该水凝胶可用作控制和特定部位药物释放的药物输送载体。阿司匹林和扑热息痛在较高pH值时均遵循非菲克扩散机制，在较低pH值时均遵循非菲克扩散机制。两种药物的释放曲线最适合一级模型。发现水凝胶对人成纤维细胞无细胞毒性，且具有生物相容性，溶血率低。因此，结果支持了这种无毒，生物友好和经过适当调整的基于多糖的水凝胶的潜力，该水凝胶可用作控制和特定部位药物释放的药物输送载体。阿司匹林和扑热息痛在较高pH值时均遵循非菲克扩散机制，在较低pH值时均遵循非菲克扩散机制。两种药物的释放曲线最适合一级模型。发现水凝胶对人成纤维细胞无细胞毒性，且具有生物相容性，溶血率低。因此，结果支持了这种无毒，生物友好和经过适当调整的基于多糖的水凝胶的潜力，该水凝胶可用作控制和特定部位药物释放的药物输送载体。

图形摘要