Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

中文翻译：

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Translin-Trax：肿瘤治疗靶向的考虑因素。

缺乏切丁酶的癌症的预后较差，这与通过Translin-Trax（Tn-Tx）核糖核酸酶降解抑制肿瘤的miRNA前体有关。Tn-Tx的抑制可能提供新的治疗干预点。然而，Tn-Tx在一系列生物过程中起作用，在这里我们考虑这种复杂性如何影响治疗设计策略。