Two recent reports by Cramer and Ben-Shem and colleagues present high-resolution structures of the yeast SAGA transcription coactivator complex. These are the first to resolve the stoichiometry and structure of the core. The core contains an octamer-like fold, flexibly links the enzymatic modules, and facilitates TBP loading onto TATA promoters.

中文翻译：

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SAGA 结构提供基因激活的机制模型。

Cramer 和 Ben-Shem 及其同事最近的两份报告展示了酵母 SAGA 转录辅激活复合物的高分辨率结构。这些是首先解决核心的化学计量和结构的问题。核心包含一个八聚体样折叠，灵活地连接酶模块，并促进 TBP 加载到 TATA 启动子上。