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SAGA Structures Provide Mechanistic Models for Gene Activation.
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2020-03-16 , DOI: 10.1016/j.tibs.2020.03.001
Jelly H M Soffers 1 , Varvara V Popova 1 , Jerry L W Workman 1
Affiliation  

Two recent reports by Cramer and Ben-Shem and colleagues present high-resolution structures of the yeast SAGA transcription coactivator complex. These are the first to resolve the stoichiometry and structure of the core. The core contains an octamer-like fold, flexibly links the enzymatic modules, and facilitates TBP loading onto TATA promoters.



中文翻译:

SAGA 结构提供基因激活的机制模型。

Cramer 和 Ben-Shem 及其同事最近的两份报告展示了酵母 SAGA 转录辅激活复合物的高分辨率结构。这些是首先解决核心的化学计量和结构的问题。核心包含一个八聚体样折叠,灵活地连接酶模块,并促进 TBP 加载到 TATA 启动子上。

更新日期:2020-03-16
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