The aqueous extract of Passiflora edulis leaves is rich in bioactive polyphenolics, with antioxidant and anti-inflammatory properties. In this study, the recovery of barrier dysfunction and the anti-inflammatory effect of P. edulis leaf aqueous extract (PELE) were evaluated using a Caco-2 monolayer model challenged with IL-1β and LPS. After inflammatory stimuli, it was observed a 28% reduction in transepithelial electrical resistance (TER) and 78% increase of LY permeability. After 48-h treatment with PELE (10 mg mL^-1), the monolayer showed 35% increase in TER after inflammatory decreases, and 67% lower LY paracellular permeability, showing a recovery of the monolayer integrity. The treatment also suppressed IL-8 production in 65%. Our results suggest that PELE is a potent source of antioxidants that may promote a protective effect by repairing the intestinal epithelial integrity.

西番莲叶的水提取物富含生物活性多酚，具有抗氧化和抗炎特性。在这项研究中，屏障功能障碍和的抗炎作用的恢复毛竹叶水性提取物（PELE）使用用IL-1β和LPS攻击的一个的Caco-2单层模型进行了评价。炎性刺激后，观察到跨上皮电阻（TER）降低28％，LY渗透性提高78％。用PELE（10 mg mL ^-1），炎症降低后，单层细胞的TER升高35％，而LY细胞旁通透性降低67％，表明单层细胞的完整性得以恢复。该处理还抑制了65％的IL-8产生。我们的研究结果表明PELE是有效的抗氧化剂来源，可通过修复肠道上皮完整性来促进保护作用。