Background

ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription. In particular, chromatin remodeling can dynamically regulate gene expression by altering accessibility of chromatin to transcription factors.

Scope of review

This review provides an overview of the importance of chromatin remodelers in the regulation of metabolic gene expression. Particular emphasis is placed on the INO80 and SWI/SNF (BAF/PBAF) chromatin remodelers in both yeast and mammals. This review details discoveries from the initial identification of chromatin remodelers in Saccharomyces cerevisiae to recent discoveries in the metabolic requirements of developing embryonic tissues in mammals.

Major conclusions

INO80 and SWI/SNF (BAF/PBAF) chromatin remodelers regulate the expression of energy metabolism pathways in S. cerevisiae and mammals in response to diverse nutrient environments. In particular, the INO80 complex organizes the temporal expression of gene expression in the metabolically synchronized S. cerevisiae system. INO80-mediated chromatin remodeling is also needed to constrain cell division during metabolically favorable conditions. Conversely, the BAF/PBAF remodeler regulates tissue-specific glycolytic metabolism and is disrupted in cancers that are dependent on glycolysis for proliferation. The role of chromatin remodeling in metabolic gene expression is downstream of the metabolic signaling pathways, such as the TOR pathway, a critical regulator of metabolic homeostasis. Furthermore, the INO80 and BAF/PBAF chromatin remodelers have both been shown to regulate heart development, the tissues of which have unique requirements for energy metabolism during development. Collectively, these results demonstrate that chromatin remodelers communicate metabolic status to chromatin and are a central component of homeostasis pathways that optimize cell fitness, organismal development, and prevent disease.

中文翻译：

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染色质重塑将代谢信号传导与基因表达联系起来。

背景

ATP依赖的染色质重塑剂是进化上保守的复合物，可改变核小体的定位以影响许多DNA模板化的过程，例如复制，修复和转录。特别是，染色质重塑可以通过改变染色质对转录因子的可及性来动态调节基因表达。

审查范围

这篇综述概述了染色质重塑剂在代谢基因表达调控中的重要性。特别强调酵母和哺乳动物中的INO80和SWI / SNF（BAF / PBAF）染色质重塑剂。这篇综述详细介绍了从酿酒酵母中染色质重塑剂的初步鉴定到哺乳动物发育中的胚胎组织代谢需要的最新发现。

主要结论

INO80和SWI / SNF（BAF / PBAF）染色质重塑剂调节啤酒酵母和哺乳动物中能量代谢途径的表达，以响应多种营养环境。尤其是，INO80复合物在代谢同步酿酒酵母中组织了基因表达的时间表达。系统。还需要INO80介导的染色质重塑，以在代谢有利的条件下限制细胞分裂。相反，BAF / PBAF重塑剂调节组织特异性糖酵解代谢，并在依赖糖酵解进行增殖的癌症中被破坏。染色质重塑在代谢基因表达中的作用在代谢信号传导途径（如TOR途径）的下游，TOR途径是代谢稳态的关键调节剂。此外，INO80和BAF / PBAF染色质重塑剂均能调节心脏发育，心脏组织在发育过程中对能量代谢具有独特的要求。总的来说，