One of the important components in tissue engineering is material structure, providing a model for fixing and the development of cells and tissues, which allows for the transport of nutrients and regulatory molecules to and from cells. The community claims the need for new materials with better properties for use in the clinic. Poly (ε-caprolactone) (PCL) is a biodegradable polymer, semi crystalline, with superior mechanical properties and has attracted an increasing interest due to its usefulness in various biomedical applications. Herein, two different methods (electrospinning versus rotary jet spinning) with different concentrations of PCL produced ultra thin-fibers each with particular characteristics, verified and analyzed by morphology, wettability, thermal and cytotoxicity features and for bacteria colonization. Different PCL scaffold morphologies were found to be dependent on the fabrication method used. All PCL scaffolds showed greater mammalian cell interactions. Most impressively, rotary-jet spun fibers showed that a special rough surface decreased bacteria colonization, emphasizing that no nanoparticle or antibiotic was used; maybe this effect is related with physical (scaffold) and/or biological mechanisms. Thus, this study showed that rotary jet spun fibers possess a special topography compared to electrospun fibers to reduce bacteria colonization and present no cytotoxicity when in contact with mammalian cells.

组织工程学中的重要组成部分之一是材料结构，它为细胞和组织的固定和发育提供了模型，从而使营养物质和调节分子可以进出细胞。社区声称需要在临床上使用具有更好性能的新材料。聚（ε-己内酯）（PCL）是具有良好机械性能的可生物降解的半结晶聚合物，由于其在各种生物医学应用中的用途，引起了越来越多的关注。本文中，使用不同浓度的PCL的两种不同方法（静电纺丝与旋转喷射纺丝）生产了具有特定特征的超细纤维，并通过形态，润湿性，热和细胞毒性特征以及细菌定植进行了验证和分析。发现不同的PCL支架形态取决于所使用的制造方法。所有PCL支架均显示出更大的哺乳动物细胞相互作用。最令人印象深刻的是，旋转喷射纺丝纤维显示出特殊的粗糙表面减少了细菌的定居，强调没有使用纳米颗粒或抗生素。也许这种作用与物理（支架）和/或生物学机制有关。因此，这项研究表明，与静电纺丝纤维相比，旋转喷射纺丝纤维具有特殊的形貌，可以减少细菌定植，并且与哺乳动物细胞接触时不具有细胞毒性。强调未使用纳米颗粒或抗生素；也许这种作用与物理（支架）和/或生物学机制有关。因此，这项研究表明，与静电纺丝纤维相比，旋转喷射纺丝纤维具有特殊的形貌，可以减少细菌定植，并且与哺乳动物细胞接触时不具有细胞毒性。强调未使用纳米颗粒或抗生素；也许这种作用与物理（支架）和/或生物学机制有关。因此，这项研究表明，与静电纺丝纤维相比，旋转喷射纺丝纤维具有特殊的形貌，可减少细菌定植，并且与哺乳动物细胞接触时不具有细胞毒性。