Abstract The multimodal therapies have showed significantly efficacy in clinical tumor treatment. Nanotechnology provides the powerful platform as multifunctional drug delivery system. Herein, graphene oxide (GO) nanosheets were prepared and modified with polyethylene glycol derivatives and lactobionic acid (LA), which improved their biocompatibility. The anticancer drug curcumin (CUR) that possess various biological effects was selected and successfully loaded onto the nanocomposites by π-π stacking. In vitro results showed that the formulation of GO-PEG/LA-CUR has good biosafety and the ability to specifically target hepatocellular carcinoma cells that overexpress asialoglycoprotein receptor (ASGPR). The in vivo experiments also demonstrated excellent biodistribution of GO-PEG/LA-CUR nanocomposites. The tumor growth was significantly inhibited in subcutaneous HCC tumor-bearing mice treated with GO-PEG/LA-CUR after near-infrared (NIR) irradiation, with a tumor inhibition rate of 86 %, demonstrating the synergistic chemo-photothermal therapy (PTT) efficacy. The therapeutic nanocomposites can be a useful PTT-combined platform for the clinical HCC treatment.

中文翻译：

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靶向纳米系统联合化学光热疗法治疗肝细胞癌

摘要 多模式治疗已在临床肿瘤治疗中显示出显着疗效。纳米技术为多功能给药系统提供了强大的平台。在此，制备氧化石墨烯 (GO) 纳米片并用聚乙二醇衍生物和乳糖酸 (LA) 进行改性，提高了它们的生物相容性。选择具有多种生物学效应的抗癌药物姜黄素 (CUR) 并通过 π-π 堆叠成功加载到纳米复合材料上。体外结果表明，GO-PEG/LA-CUR制剂具有良好的生物安全性和特异性靶向过表达去唾液酸糖蛋白受体（ASGPR）的肝细胞癌细胞的能力。体内实验还证明了 GO-PEG/LA-CUR 纳米复合材料的优异生物分布。近红外（NIR）照射后，用GO-PEG/LA-CUR处理的皮下HCC荷瘤小鼠的肿瘤生长受到显着抑制，肿瘤抑制率为86％，证明了协同化学光热疗法（PTT）功效。治疗性纳米复合材料可以成为临床 HCC 治疗的有用的 PTT 组合平台。