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Familial Hypercholesterolemia and Atherosclerosis: Animal Models and Therapeutic Advances
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.tem.2020.02.007
Suowen Xu 1 , Jianping Weng 1
Affiliation  

Familial hypercholesterolemia (FH), mainly arising from loss-of-function mutation of the low-density lipoprotein receptor (LDLR), is a life-threatening inherited cardiometabolic disorder with limited therapies. In a recent study, Zhao et al. created a new model of FH and demonstrate that LDLR gene editing protects against both FH and atherosclerosis.

中文翻译:

家族性高胆固醇血症和动脉粥样硬化:动物模型和治疗进展

家族性高胆固醇血症 (FH) 主要由低密度脂蛋白受体 (LDLR) 的功能丧失突变引起,是一种危及生命的遗传性心脏代谢疾病,治疗方法有限。在最近的一项研究中,赵等人。创建了一个新的 FH 模型并证明 LDLR 基因编辑可以预防 FH 和动脉粥样硬化。
更新日期:2020-05-01
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