Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients’ health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancer patients in Ethiopia. A hospital-based cross-sectional study was conducted from January to June 2018 at the oncology unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 404 cervical cancer patients were interviewed using validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), cervical cancer module (EORTC QLQ-CX24), and Euro Quality of Life Group’s 5-Domain Questionnaires 5-Levels (EQ-5D) questionnaires. ANOVA test was used to determine the effect of patients’ characteristics on mean scores of the different domains of HRQoL and stepwise multivariable logistic regression was performed to identify predictors of HRQoL. Coefficients of level-specific utility values obtained from a hybrid regression model for the Ethiopian general population were used to compute utility. The mean age of patients was 52.1 ± 10.4 years and 379 (93.8%) of the patients were receiving service at the outpatient clinic. About one-third (35%) of patients were diagnosed with stage IV cervical cancer. Mean global health status/QoL, mean utility and visual analog scale scores were 48.3 ± 23.77, 0.77 and 65.7 ± 20.83, respectively. Physical functioning (AOR = 4.98, 95% CI:2.16–11.49), emotional functioning (AOR = 5.25, 95% CI:2.26–12.17), pain (AOR = 5.79, 95% CI:2.30–14.57), and symptom experience (AOR = 4.58, 95% CI:1.95–10.79) were associated with patients’ HRQoL. Cervical cancer significantly affects patient’s HRQoL and hence, efforts to improve HRQoL should be commenced especially in terms of physical and emotional functioning, pain, and symptom experience.

中文翻译：

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埃塞俄比亚亚的斯亚贝巴的提库尔·安贝萨专科医院的子宫颈癌患者的健康相关生活质量和相关因素。

在埃塞俄比亚，宫颈癌是女性中最常见的癌症。疾病负担及其治疗会对患者的健康相关生活质量（HRQoL）产生不利影响。我们旨在调查埃塞俄比亚宫颈癌患者的HRQoL及其预测因子。一项基于医院的横断面研究于2018年1月至6月在埃塞俄比亚亚的斯亚贝巴的提库尔·安贝萨专科医院的肿瘤科进行。使用经过验证的Amharic版本的欧洲癌症研究和治疗模块（EORTC QLQ-C30），宫颈癌模块（EORTC QLQ-CX24）和Euro Life of Life Group的5域网，对404名宫颈癌患者进行了采访。问卷5级（EQ-5D）问卷。使用ANOVA检验确定患者特征对HRQoL不同域的平均得分的影响，并进行逐步多变量logistic回归以确定HRQoL的预测因子。从埃塞俄比亚总人口的混合回归模型中获得的特定水平效用值的系数用于计算效用。患者的平均年龄为52.1±10.4岁，其中379位患者（93.8％）在门诊接受服务。大约三分之一（35％）的患者被诊断出患有IV期宫颈癌。平均总体健康状况/生活质量，平均效用和视觉模拟量表得分分别为48.3±23.77、0.77和65.7±20.83。身体功能（AOR = 4.98，95％CI：2.16–11.49），情绪功能（AOR = 5.25，95％CI：2.26–12.17），疼痛（AOR = 5.79，95％CI：2.30–14.57），患者的HRQoL与症状经历（AOR = 4.58，95％CI：1.95–10.79）相关。宫颈癌会显着影响患者的HRQoL，因此，应该开始努力改善HRQoL，尤其是在身体和情绪功能，疼痛和症状体验方面。