Endotoxin is ubiquitous in the environment, but its clustering with indoor allergens is not well characterized. This study examined the clustering patterns of endotoxin with allergens in house dust and their association with asthma outcomes. We analyzed data from 6963 participants of the 2005–2006 National Health and Nutrition Examination Survey. House dust sampled from bedroom floor and bedding was evaluated for endotoxin and allergens from fungi, cockroach, dog, cat, mites, and rodents. Two-step cluster analysis and logistic regressions were performed to identify the clustering patterns and their associations with current asthma and wheeze in the past 12 months, adjusting for covariates. Of the homes, 17.8% had low endotoxin and allergen levels in house dust (Cluster 1). High endotoxin level clustered with Alternaria and pet allergens in the homes of participants with a high socioeconomic status who own pets (Cluster 2) (48.9%). High endotoxin clustered with Aspergillus, dust mites, cockroach, and rodent allergens in the homes of participants with low socioeconomic status (Cluster 3) (33.3%). Compared to Cluster 1, Cluster 2 was associated with higher asthma prevalence (OR 1.42, 95% CI: 1.06–1.91) and wheeze (OR 1.32, 95% CI: 1.07–1.63). Cluster 3 was positively associated with wheeze only in participants sensitized to inhalant allergens (OR 1.42, 95% CI: 1.06–1.91) or exposed to tobacco smoke (OR 1.72, 95% CI: 1.15–2.60). The clustering of endotoxin with allergens in dust from homes with pets or of people with low socioeconomic status is associated with asthma and wheeze.

中文翻译：

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美国国家研究中的内毒素与室内灰尘中的过敏原聚集和哮喘结果。


内毒素在环境中普遍存在，但其与室内过敏原的聚集性尚不明确。这项研究检查了室内灰尘中内毒素与过敏原的聚集模式及其与哮喘结果的关系。我们分析了 2005-2006 年全国健康和营养检查调查的 6963 名参与者的数据。对从卧室地板和床上用品中采集的室内灰尘样本进行了内毒素和来自真菌、蟑螂、狗、猫、螨虫和啮齿动物的过敏原的评估。进行两步聚类分析和逻辑回归，以确定聚类模式及其与过去 12 个月内当前哮喘和喘息的关联，并调整协变量。在 17.8% 的家庭中，室内灰尘中的内毒素和过敏原水平较低（集群 1）。在拥有宠物且社会经济地位较高的参与者的家中，内毒素水平较高，其中有链格孢属和宠物过敏原（集群 2）（48.9%）。在社会经济地位较低的参与者家中，内毒素含量较高，包括曲霉菌、尘螨、蟑螂和啮齿动物过敏原（聚类 3）（33.3%）。与聚类 1 相比，聚类 2 与较高的哮喘患病率（OR 1.42，95% CI：1.06–1.91）和喘息患病率（OR 1.32，95% CI：1.07–1.63）相关。仅在对吸入性过敏原敏感（OR 1.42，95% CI：1.06–1.91）或暴露于烟草烟雾（OR 1.72，95% CI：1.15–2.60）的参与者中，聚类 3 与喘息呈正相关。有宠物的家庭或社会经济地位较低的人的灰尘中内毒素和过敏原的聚集与哮喘和喘息有关。