Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults. We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100. The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.

中文翻译：

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在基线时不存在重度冠状动脉钙化的情况下，甘油三酸酯葡萄糖指数是冠状动脉钙化进展的独立预测因子。

有关甘油三酸酯葡萄糖（TyG）指数与冠状动脉钙化（CAC）进展之间关系的数据有限。这项纵向研究评估了无症状成人中TyG指数与CAC进展的相关性。我们纳入了12326名无症状的韩国成年人，他们接受了至少两次CAC评估。使用ln（空腹甘油三酸酯[mg / dL]×空腹葡萄糖[mg / dL] / 2）测定TyG指数。CAC进展定义为基线平方根（√）与随访冠状动脉钙化评分（CACS）（Δ√转化CACS）之差≥2.5。年度化Δ√转换的CACS定义为Δ√转换的CACS除以扫描间隔。在平均3.3年中，CAC进展的总发生率为30.6％。CAC进展的发生率（第一组[最低]：22.7％，第二组：[31.7％] 第三组[最高]：37.5％，P <0.001）和年化Δ√转化的CACS（第一组：0.46±1.44 vs.第二组：0.71±2.02，而第三组：0.87±1.75，P <0.001）显着升高随着TyG指数三分位数的增加。多元线性回归分析表明，TyG指数与年化Δ√转化的CACS相关（β= 0.066，P = 0.036）。在多元逻辑回归分析中，在基线CACS≤100时，TyG指数与CAC进展密切相关。TyG指数是CAC进展的独立预测因子，尤其是在没有重度基线CAC的成年人中。多元线性回归分析表明，TyG指数与年化Δ√转化的CACS相关（β= 0.066，P = 0.036）。在多元逻辑回归分析中，在基线CACS≤100时，TyG指数与CAC进展密切相关。TyG指数是CAC进展的独立预测因子，尤其是在没有重度基线CAC的成年人中。多元线性回归分析表明，TyG指数与年化Δ√转化的CACS相关（β= 0.066，P = 0.036）。在多元逻辑回归分析中，在基线CACS≤100时，TyG指数与CAC进展密切相关。TyG指数是CAC进展的独立预测因子，尤其是在没有重度基线CAC的成年人中。