Rh(III)‐Catalyzed Selective ortho‐C−H Amination of Benzoic Acids with Anthranils: A Facile Access to Anthranilic Acid Derivatives (AAs),ChemCatChem

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Rh(III)‐Catalyzed Selective ortho‐C−H Amination of Benzoic Acids with Anthranils: A Facile Access to Anthranilic Acid Derivatives (AAs)
ChemCatChem ( IF 3.8 ) Pub Date : 2020-03-13 , DOI: 10.1002/cctc.202000052
Yang Gao ₁ , Jianhong Nie ₁ , Yibiao Li ₂ , Guilan Liao ₁ , Yanping Huo ₁ , Xiao‐Qiang Hu ₃

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An efficient Rh(III)‐catalyzed Csp²‐H amination protocol of benzoic acids with anthranils was developed for the rapid assembly of valuable anthranilic acid derivatives (AAs). The weakly coordinating carboxyl acted as a directing group and was further transformed to an ester group after facilitating the first C−H amination process. This reaction features good functional group tolerance, mild conditions and operational simplicity. The synthetic potential of this methodology was demonstrated by the synthesis of various useful heterocycles and derivatives.

中文翻译：

Rh（III）催化的苯甲酸与邻氨基苯甲酸的选择性邻-C H胺化反应：邻氨基苯甲酸衍生物（AAs）的便捷获得

为快速组装有价值的邻氨基苯甲酸衍生物（AAs），开发了一种高效的Rh（III）催化的苯甲酸与蒽基的Csp ² -H氨基化反应方案。弱配位羧基充当导向基团，并在促进第一个CH氨基化过程后进一步转化为酯基。该反应具有良好的官能团耐受性，温和的条件和操作简便性。通过各种有用的杂环和衍生物的合成证明了该方法的合成潜力。

更新日期：2020-03-13

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