Vascular endothelial growth factor-loaded poly-lactic-co-glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats.,Chemical Biology & Drug Design

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Vascular endothelial growth factor-loaded poly-lactic-co-glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats.
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2020-03-13 , DOI: 10.1111/cbdd.13681
Xian-Yue Meng ₁ , An-Qi Huang ₁ , Afsar Khan ₂ , Li Zhang ₁ , Xiao-Qian Sun ₁ , Hao Song ₃ , Jun Han ₄ , Qian-Ru Sun ₅ , Yu-Dan Wang ₆ , Xue-Li Li ₁

Affiliation

Vascular endothelial growth factor (VEGF) had neuroprotective effects on dopaminergic (DA) neurons. In order to overcome the gastrointestinal digestion and bioaccessibility, VEGF was encapsulated with poly‐lactic‐co‐glycolic acid nanospheres (NS) in order to prevent the VEGF degradation until its release. The caudal administration of VEGF and NS encapsulated VEGF at different doses (1.0, 10.0, and 100.0 ng/ml) on the rats with Parkinson's disease lesion was evaluated. Intravenous injected VEGF at the dose of 1 ng/ml displayed the strongest neuroprotective effect than other groups as well as the stereotaxic group. The NS encapsulated with VEGF can pass through blood–brain barrier and protect the DA neurons. There was no significant difference between intravenous injection method and stereotaxic method, while the first method is simpler and convenient. Injection of NS encapsulated with VEGF may become a valuable neurorescuing therapeutic approach for Parkinson's disease.

中文翻译：

装有血管内皮生长因子的聚乳酸-乙醇酸共聚物控释纳米颗粒可保护帕金森大鼠的多巴胺能神经元。

血管内皮生长因子（VEGF）对多巴胺能（DA）神经元具有神经保护作用。为了克服胃肠消化和生物可及性，将VEGF用聚乳酸-乙醇酸纳米球（NS）包裹起来，以防止VEGF降解直至释放。评价了帕金森氏病病变大鼠的尾部不同剂量（1.0、10.0和100.0 ng / ml）的VEGF和NS包裹的VEGF。静脉注射1 ng / ml的VEGF显示出比其他组以及立体定位组最强的神经保护作用。VEGF包裹的NS可以穿过血脑屏障并保护DA神经元。静脉注射法和立体定向法之间没有显着差异，而第一种方法更简单方便。注射包裹有VEGF的NS可能成为帕金森氏病有价值的神经挽救治疗方法。

更新日期：2020-03-13

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