The complement system represents one of the evolutionary oldest arms of our immune system and is commonly recognized as a liver-derived and serum-active system critical for providing protection against invading pathogens. Recent unexpected findings, however, have defined novel and rather "uncommon" locations and activities of complement. Specifically, the discovery of an intracellularly active complement system-the complosome-and its key role in the regulation of cell metabolic pathways that underly normal human T cell responses have taught us that there is still much to be discovered about this system. Here, we summarize the current knowledge about the emerging functions of the complosome in T cell metabolism. We further place complosome activities among the non-canonical roles of other intracellular innate danger sensing systems and argue that a "location-centric" view of complement evolution could logically justify its close connection with the regulation of basic cell physiology.

中文翻译：

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补体和人类 T 细胞代谢：位置，位置，位置。


补体系统代表了我们免疫系统中进化最古老的分支之一，通常被认为是肝源性血清活性系统，对于提供针对入侵病原体的保护至关重要。然而，最近的意外发现定义了新颖且相当“不常见”的补体位置和活动。具体来说，细胞内活性补体系统（复合体）的发现及其在正常人类 T 细胞反应下的细胞代谢途径调节中的关键作用告诉我们，关于该系统还有很多有待发现。在这里，我们总结了目前关于复合体在 T 细胞代谢中的新兴功能的知识。我们进一步将复合体活动置于其他细胞内先天危险感知系统的非典型作用中，并认为补体进化的“以位置为中心”的观点可以在逻辑上证明其与基本细胞生理学调节的密切联系。