Neuronal loss in the substantia nigra pars compacta (SNpc) in Parkinson disease (PD) is not uniform, as dopamine neurons from the ventral tier are lost more rapidly than those of the dorsal tier. Identifying the intrinsic differences that account for this differential vulnerability may provide a key for developing new treatments for PD.

中文翻译：

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腹侧和背侧中脑多巴胺神经元的人类特异性转录组

帕金森病 (PD) 中黑质致密部 (SNpc) 的神经元丢失并不统一，因为腹侧多巴胺神经元的丢失速度比背侧多巴胺神经元丢失的速度更快。确定导致这种差异脆弱性的内在差异可能为开发 PD 新疗法提供关键。