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A new and green approach for regiospecific synthesis of novel chromeno‐triazolopyrimidin using tungstic acid immobilized MCM‐41 as a reusable catalyst
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2020-03-15 , DOI: 10.1002/jhet.3960
Sedigheh Akrami 1 , Bahador Karami 1 , Mahnaz Farahi 1
Affiliation  

A novel, eco‐friendly and fast route has been developed for the synthesis of new and known triazolo[1,5‐a ]pyrimidin fused chromone derivatives via a one pot three‐component reaction of 3‐amino‐1,2,4‐triazoles, aromatic aldehydes and 4‐hydroxycoumarin in aqueous medium at room temperature. These reactions are catalyzed by MCM‐41‐HWO4 as a safe and recyclable mesoporous solid acid. It combines successfully the synergistic effect of green chemistry with nanocatalysis. The yields are high and the products were characterized by 1H NMR, 13CNMR spectra and elemental analysis.

中文翻译:

一种新的绿色方法,用于固定化钨酸的MCM-41作为可重复使用的催化剂,用于区域特异性合成新型色诺三唑并嘧啶

通过3-氨基1,2,4,3-一锅三组分反应,开发了一种新颖,环保,快速的路线,用于合成新的和已知的三唑并[1,5- a ]嘧啶融合的色酮衍生物。室温下,在水性介质中加入三唑,芳香醛和4-羟基香豆素。这些反应由MCM-41-HWO 4催化,是一种安全且可回收的中孔固体酸。它成功地将绿色化学与纳米催化的协同作用结合在一起。产率高,并且产物通过1 H NMR,13 CNMR光谱和元素分析来表征。
更新日期:2020-03-15
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