A greener, rapid and regioselective “on water” synthesis of spirooxindole‐oxazoline by the reaction of isatin and isocyanoacetate at room temperature is described. The developed protocol has the advantage of being atom‐economical, eco‐friendly, and benign reaction conditions. Broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive. The synthesized compounds have been fully characterized with spectral analysis.

中文翻译：

---

Isatin和异氰基乙酸酯“在水上”反应可快速，区域选择性地进入螺旋吡咯并恶唑啉

描述了一种在室温下通过Isatin和异氰基乙酸酯的反应进行绿色，快速和区域选择性的“水上”合成螺环吲哚-恶唑啉的方法。所开发的协议具有原子经济，生态友好和良性反应条件的优势。较宽的底物范围，实验上简单的步骤以及易于纯化的高收率产品进一步使该方法具有吸引力。合成的化合物已通过光谱分析充分表征。