In article number 1900446, Mateus Borba Cardoso and co‐workers develop a nanoparticle dual functionalization strategy that allows selective system targetability by minimizing undesirable and non‐specific protein adsorption. These structures are able to selectively interact with L540 lymphocytic cells, likely due to the preferential binding of Ki‐1 mAb grafted on the nanoparticles surface to TNFRSF8 transmembrane protein overexpressed on CD30⁺ lymphoma cells.

中文翻译：

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两性离子官能化的纳米颗粒：通过嫁接到两性离子官能化的纳米颗粒上的单克隆抗体对淋巴瘤细胞的选择性靶向（部分，系统特性3/2020）

Mateus Borba Cardoso及其同事在编号1900446中开发了一种纳米粒子双重功能化策略，该策略可通过最大程度地减少不良和非特异性蛋白质的吸附来实现选择性的系统靶向性。这些结构能够与L540淋巴细胞选择性相互作用，这可能是由于嫁接到纳米颗粒表面的Ki-1 mAb与CD30 ⁺淋巴瘤细胞上过表达的TNFRSF8跨膜蛋白的优先结合所致。