Graphene quantum dots (GQDs) was synthesized using a simple, rapid and affordable method and decorated with selenium at different molar ratios for the first time to obtain an efficient sample for use in photodynamic therapy. Surface modification of GQDs was carried out using polyethylene glycol (PEG) for conjugation with protoporphyrin IX (PpIX). Synthesized GQDs (Se: 0.3%) at 180°C had an emission spectrum that fairly coincided with the absorption profile of PpIX. A relative decrease of about 62.48% in the emission intensity of anthracene was recorded under illumination with UVC light in the presence of GQDs (Se: 0.3%) and the reduction for clung GQDs (Se: 0.3%) and PpIX during 90 min was about 70.68%. Singlet oxygen (¹O₂) generation was examined using a chemical method that showed significant enhancement in decomposition rate constant in clung GQDs–PEG–PpIX compared with GQDs and PpIX alone. Afterglow over 600 s showed that GQDs (Se: 0.3%) could be effective for near skin and even deep tumours.

中文翻译：

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高余辉硒修饰石墨烯量子点的制备与表征，用于光动力治疗。

石墨烯量子点（GQDs）使用一种简单，快速且负担得起的方法合成，并首次用不同摩尔比的硒修饰，以获得用于光动力疗法的有效样品。GQD的表面修饰是使用聚乙二醇（PEG）与原卟啉IX（PpIX）偶联进行的。180°C时合成的GQD（Se：0.3％）的发射光谱与PpIX的吸收曲线完全吻合。在存在GQDs（Se：0.3％）的情况下，在UVC光照射下，蒽的发射强度相对降低了约62.48％，而在90分钟内，固着的GQDs（Se：0.3％）和PpIX的降低幅度约为60％。 70.68％。单线态氧（¹ O ₂）的产生使用化学方法进行了检查，与单独使用GQD和PpIX相比，该方法显示了紧密GQDs-PEG-PpIX的分解速率常数显着提高。超过600 s的余辉表明，GQD（硒：0.3％）可能对皮肤附近甚至深部肿瘤有效。