Abstract

As an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) in vivo. The experimental results showed that the BCNDs were successfully prepared with high biosafety in vivo and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX in vivo and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic.

 抽象的

作为注射型抗癌药物递送系统，纳米载体的生物安全性是其临床应用最重要的前提。我们研究的目的是合成特殊的超声响应性高度生物相容性壳聚糖纳米液滴（BCND），观察它们在体内时空控制阿霉素（DOX）的递送。实验结果表明，成功制备的BCNDs具有较高的体内生物安全性和良好的超声成像能力。 DOX-BCNDs在体内促进DOX的抗癌作用并抑制肿瘤的发展。它们还减少了对心脏和肾脏的副作用。综上所述，BCNDs是一种新型智能纳米载体，具有较高的生物相容性和功效，在临床上具有巨大的应用潜力。