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A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-06 , DOI: 10.1039/d0tb00361a Na Yang 1 , Ming Zhu 1 , Guochao Xu 1 , Ning Liu 1 , Cong Yu 2
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-06 , DOI: 10.1039/d0tb00361a Na Yang 1 , Ming Zhu 1 , Guochao Xu 1 , Ning Liu 1 , Cong Yu 2
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The development of new multi-functional dressing materials that effectively combine excellent antibacterial and wound healing promotion properties are highly desirable in modern biomedical research and clinical practice. In this study, a new near-infrared photo-responsive dressing material (HG1-CW) was fabricated based on a dodecyl-modified and Schiff base-linked chitosan hydrogel, a photothermal agent (WS2 nanosheets), and an antimicrobial drug (ciprofloxacin). This nanocomposite dressing possesses the advantages of being injectable, self-adapting, rapidly molding, and has good tissue adherence and excellent biocompatibility. The positive charge, macropore, and alkyl chain of the hydrogel helped to capture and restrict the bacteria. Under the irradiation of near-infrared light, the WS2 nanosheets produced a large amount of heat and simultaneously, the antibiotic was triggered to release in an on-demand fashion at the wound site, leading to the bacterial death. This synergistic therapy combining the photothermal effect and the spatially and temporally controlled drug release effectively avoided the shortcomings of each of the two individual treatment modes, and the outstanding sterilizing effect was verified by both the in vitro antibacterial tests and an S. aureus-infected mouse wound model. Furthermore, the dressing nanocomposite showed a good anti-oxidation activity, which could effectively eliminate the inflammatory responses triggered by the dead bacteria left in the infected area, avoid secondary damage to the wound tissue, and promote wound healing. This multifunctional dressing demonstrates good potential in clinical applications.
中文翻译：
一种近红外光响应多功能纳米复合水凝胶，用于高效，协同的抗菌伤口治疗和促进愈合。
有效结合优异的抗菌和伤口愈合促进性能的新型多功能敷料在现代生物医学研究和临床实践中非常需要。在这项研究中，基于十二烷基改性和席夫碱连接的壳聚糖水凝胶，光热剂（WS2纳米片）和抗菌药物（环丙沙星）制造了一种新的近红外光响应敷料（HG1-CW）。 。该纳米复合敷料具有可注射，自适应，快速成型的优点，并具有良好的组织粘附性和优异的生物相容性。水凝胶的正电荷，大孔和烷基链有助于捕获和限制细菌。在近红外光的照射下，WS2纳米片产生了大量的热量，同时，触发了抗生素在伤口部位按需释放的方式，导致细菌死亡。这种协同疗法结合了光热效应和时空控制下的药物释放，有效地避免了两种单独治疗方式各自的缺点，并且通过体外抗菌测试和金黄色葡萄球菌感染的小鼠均证实了优异的灭菌效果。伤口模型。此外，敷料纳米复合材料显示出良好的抗氧化活性，可以有效消除感染区域残留细菌引起的炎症反应，避免对伤口组织的继发性损伤，并促进伤口愈合。这种多功能敷料在临床应用中显示出良好的潜力。
更新日期：2020-03-14
中文翻译：
一种近红外光响应多功能纳米复合水凝胶，用于高效，协同的抗菌伤口治疗和促进愈合。
有效结合优异的抗菌和伤口愈合促进性能的新型多功能敷料在现代生物医学研究和临床实践中非常需要。在这项研究中，基于十二烷基改性和席夫碱连接的壳聚糖水凝胶，光热剂（WS2纳米片）和抗菌药物（环丙沙星）制造了一种新的近红外光响应敷料（HG1-CW）。 。该纳米复合敷料具有可注射，自适应，快速成型的优点，并具有良好的组织粘附性和优异的生物相容性。水凝胶的正电荷，大孔和烷基链有助于捕获和限制细菌。在近红外光的照射下，WS2纳米片产生了大量的热量，同时，触发了抗生素在伤口部位按需释放的方式，导致细菌死亡。这种协同疗法结合了光热效应和时空控制下的药物释放，有效地避免了两种单独治疗方式各自的缺点，并且通过体外抗菌测试和金黄色葡萄球菌感染的小鼠均证实了优异的灭菌效果。伤口模型。此外，敷料纳米复合材料显示出良好的抗氧化活性，可以有效消除感染区域残留细菌引起的炎症反应，避免对伤口组织的继发性损伤，并促进伤口愈合。这种多功能敷料在临床应用中显示出良好的潜力。
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