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Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-06 , DOI: 10.1039/d0tb00243g Linhua Liao 1 , Dong Cen 2 , Yike Fu 1 , Bin Liu 1 , Chao Fang 1 , Yifan Wang 2 , Xiujun Cai 2 , Xiang Li 1 , Hao Bin Wu 1 , Gaorong Han 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-05-06 , DOI: 10.1039/d0tb00243g Linhua Liao 1 , Dong Cen 2 , Yike Fu 1 , Bin Liu 1 , Chao Fang 1 , Yifan Wang 2 , Xiujun Cai 2 , Xiang Li 1 , Hao Bin Wu 1 , Gaorong Han 1
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Developing drug delivery platforms that can modulate a tumor microenvironment and deliver multiple therapeutics to targeted tumors is critical for efficient cancer treatment. Achieving these platforms still remains a great challenge. Herein, biodegradable nanocapsules based on MnFe hydroxides (H-MnFe(OH)x) have been developed as a new type of cargo delivery with high loading capacity and catalytic activity, enabling synergetic therapy with promoted efficacy by relieving hypoxia in tumor tissues. As a proof of concept, a photosensitizer (indocyanine green, ICG) and a chemotherapeutic drug (doxorubicin, DOX) are co-loaded in nanocapsules and selectively released upon degradation of the nanocapsules in the acidic tumor microenvironment, and are promoted by near infrared irradiation. Meanwhile, Mn2+/Fe3+ ions released from the degradation of nanocapsules catalyze the conversion of H2O2 in a tumor microenvironment into oxygen, which modulates tumor hypoxia and dramatically boosts multimodal therapies. Remarkable synergistic anticancer outcomes have been demonstrated both in vitro and in vivo, paving the way towards future multifunctional therapeutic platforms.
中文翻译：
可生物降解的MnFe氢氧化物纳米胶囊可实现多种治疗方法的交付和低氧调节的肿瘤治疗。
开发可以调节肿瘤微环境并将多种治疗剂递送至靶向肿瘤的药物递送平台对于有效的癌症治疗至关重要。实现这些平台仍然是一个巨大的挑战。在此，基于MnFe氢氧化物（H-MnFe（OH）x）的可生物降解的纳米胶囊已被开发为具有高负载能力和催化活性的新型货物递送，通过减轻肿瘤组织中的缺氧而实现了具有协同功效的协同疗法。作为概念验证，将光敏剂（吲哚菁绿，ICG）和化学治疗药物（阿霉素，DOX）共同装载在纳米胶囊中，并在酸性肿瘤微环境中降解纳米胶囊后选择性释放，并通过近红外辐射促进。与此同时，纳米胶囊降解释放的Mn2 + / Fe3 +离子催化肿瘤微环境中的H2O2转化为氧气，从而调节肿瘤缺氧并显着促进了多模式疗法。在体外和体内均已显示出显着的协同抗癌效果，为未来的多功能治疗平台铺平了道路。
更新日期：2020-03-14
中文翻译：
可生物降解的MnFe氢氧化物纳米胶囊可实现多种治疗方法的交付和低氧调节的肿瘤治疗。
开发可以调节肿瘤微环境并将多种治疗剂递送至靶向肿瘤的药物递送平台对于有效的癌症治疗至关重要。实现这些平台仍然是一个巨大的挑战。在此，基于MnFe氢氧化物（H-MnFe（OH）x）的可生物降解的纳米胶囊已被开发为具有高负载能力和催化活性的新型货物递送，通过减轻肿瘤组织中的缺氧而实现了具有协同功效的协同疗法。作为概念验证，将光敏剂（吲哚菁绿，ICG）和化学治疗药物（阿霉素，DOX）共同装载在纳米胶囊中，并在酸性肿瘤微环境中降解纳米胶囊后选择性释放，并通过近红外辐射促进。与此同时，纳米胶囊降解释放的Mn2 + / Fe3 +离子催化肿瘤微环境中的H2O2转化为氧气，从而调节肿瘤缺氧并显着促进了多模式疗法。在体外和体内均已显示出显着的协同抗癌效果，为未来的多功能治疗平台铺平了道路。
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