Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers.,Analyst

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Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers.
Analyst ( IF 3.6 ) Pub Date : 2020-03-23 , DOI: 10.1039/d0an00345j
Zhaoyi Liu ₁ , Yong Zhang , Bing Li , Xiang Ren , Hongmin Ma , Qin Wei

Affiliation

No-wash detection of small molecules in real samples has been attracting attention in the field of sensors including electroanalytical biosensors. Based on the direct electrochemical oxidation of fluorene-9-bisphenol (BHPF) on a CoN nanoarray electrode, we developed a ratiometric molecularly imprinted polymeric electrochemical (MIP-EC) sensor to realize no-wash detection of BHPF in serum and tap water. The CoN nanoarray in situ grown on carbon cloth (CC) served as the working electrode, which could load the electroactive toluidine blue (TB) and be modified by the MIPs. As the MIP concentration on the modified electrode surface was increased, the amount of BHPF exposed on the electrode surface increased and the amount of exposed TB decreased. Thus, the values of ΔITB and ΔIBHPF decreased and increased, respectively, with an increasing amount of BHPF. Therefore, a ratiometric strategy was established by using the value of ΔITB/ΔIBHPF as the instruction response to realize detection of BHPF with high sensitivity and reliability. The developed ratiometric MIP-EC sensor showed strong anti-interference ability, good detection reproducibility and stability towards no-wash detection of BHPF as shown from tests with real samples. This work can further provide theoretical and practical guidance for the detection of other familiar small molecules.

中文翻译：

基于CoN纳米阵列与分子印迹聚合物相结合的新型比率式电化学传感器，用于无洗检测芴9-双酚。

在包括电分析生物传感器在内的传感器领域，对真实样品中的小分子进行不清洗检测已引起人们的关注。基于CoN纳米阵列电极上芴9-双酚（BHPF）的直接电化学氧化，我们开发了一种比例式分子印迹聚合物电化学（MIP-EC）传感器，以实现对血清和自来水中BHPF的免清洗检测。在碳布（CC）上原位生长的CoN纳米阵列用作工作电极，可以加载电活性甲苯胺蓝（TB）并通过MIP进行修饰。随着修饰电极表面上MIP浓度的增加，暴露在电极表面上的BHPF数量增加，暴露的TB数量减少。因此，ΔITB和ΔIBHPF的值分别减小和增大，随着BHPF数量的增加。因此，以ΔITB/ΔIBHPF的值作为指令响应，建立了比例策略，以高灵敏度，高可靠性实现对BHPF的检测。如实样测试所示，开发的比例式MIP-EC传感器具有很强的抗干扰能力，良好的检测重现性和对BHPF的免洗检测的稳定性。这项工作可以进一步为检测其他熟悉的小分子提供理论和实践指导。真实样品的测试显示，BHPF的免洗检测具有良好的检测重现性和稳定性。这项工作可以进一步为检测其他熟悉的小分子提供理论和实践指导。真实样品的测试显示，BHPF的免洗检测具有良好的检测重现性和稳定性。这项工作可以进一步为检测其他熟悉的小分子提供理论和实践指导。

更新日期：2020-03-13

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