The flood of recent cancer genomic data requires a coherent model that can sort out the findings to systematically explain clonal evolution and the resultant intra-tumor heterogeneity (ITH). Here, we present a new mathematical model designed to computationally simulate the evolution of cancer cells. The model connects the well-known hallmarks of cancer with the specific mutational states of tumor-related genes. The cell behavior phenotypes are stochastically determined, and the hallmarks probabilistically interfere with the phenotypic probabilities. In turn, the hallmark variables depend on the mutational states of tumor-related genes. Thus, our software can deepen our understanding of cancer-cell evolution and generation of ITH.

中文翻译：

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tugHall：基于癌症和肿瘤相关基因特征的癌细胞进化模拟器。

最近的癌症基因组数据的泛滥需要一个连贯的模型，该模型可以整理发现以系统地解释克隆进化和由此产生的肿瘤内异质性（ITH）。在这里，我们提出了一种新的数学模型，旨在计算地模拟癌细胞的进化。该模型将癌症的著名特征与肿瘤相关基因的特定突变状态联系起来。细胞行为表型是随机确定的，这些标志概率地干扰了表型的概率。反过来，标志变量取决于肿瘤相关基因的突变状态。因此，我们的软件可以加深我们对癌细胞进化和ITH产生的理解。