Today, photoacoustic imaging (PAI) is widely used to study diseases in the skin, brain, cardiovascular, and other parts. However, these studies are often carried out using physiological slices or model animals, which indicate that many PAI techniques can only be used in the laboratory. In order to promote the transformation of PAI into clinical applications or, more specifically, to extend the application of photoacoustic (PA) microscopy to areas such as the oral cavity, throat, cervix, and abdominal viscera which are difficult to detect with conventional PA microscopy systems, a PAI pen was developed. The PAI pen can be handheld and can perform forward detection and lateral detection. The imaging area is a 2.4 mm diameter circular area. In addition, it can provide a high-speed imaging mode of four frames per second and a high-resolution imaging mode of 0.25 frames per second to meet the different needs of clinical users. In this Letter, the performance of the PAI pen was tested by imaging the phantom and the human oral cavity. The experimental results prove that the PAI pen can clearly image the microvessels of the oral cavity, which indicates that it has the same imaging capability for other similar areas and has a good prospect for assisting the diagnosis of related diseases.

中文翻译：

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高速双视角光声成像笔

如今，光声成像（PAI）被广泛用于研究皮肤，大脑，心血管和其他部位的疾病。但是，这些研究通常是使用生理切片或模型动物进行的，这表明许多PAI技术只能在实验室中使用。为了促进将PAI转变为临床应用，或更具体地说，将光声（PA）显微镜的应用扩展到常规PA显微镜难以检测的诸如口腔，咽喉，子宫颈和腹腔内脏的区域系统，开发了PAI笔。PAI笔可以是手持式的，并且可以执行正向检测和横向检测。成像区域是直径为2.4毫米的圆形区域。此外，它可以提供每秒四帧的高速成像模式和每秒0.25帧的高分辨率成像模式，以满足临床用户的不同需求。在这封信中，PAI笔的性能通过对人体模型和人体口腔成像进行了测试。实验结果证明，PAI笔可以清晰地显示口腔微血管的图像，这表明它在其他类似区域具有相同的成像能力，在协助相关疾病的诊断方面具有良好的前景。