RIG-I-like receptors: their regulation and roles in RNA sensing.,Nature Reviews Immunology

当前位置： X-MOL 学术 › Nat. Rev. Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

RIG-I-like receptors: their regulation and roles in RNA sensing.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-03-13 , DOI: 10.1038/s41577-020-0288-3
Jan Rehwinkel ₁ , Michaela U Gack ₂

Affiliation

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs can trigger RLR activation; this can lead to an effective antiviral response but also immunopathology if RLR activities are uncontrolled. In this Review, we discuss recent advances in our understanding of the types of RNA sensed by RLRs in the contexts of viral infection, malignancies and autoimmune diseases. We further describe how the activity of RLRs is controlled by host regulatory mechanisms, including RLR-interacting proteins, post-translational modifications and non-coding RNAs. Finally, we discuss key outstanding questions in the RLR field, including how our knowledge of RLR biology could be translated into new therapeutics.

中文翻译：

RIG-I 样受体：它们在 RNA 传感中的调节和作用。

视黄酸诱导基因 I (RIG-I) 样受体 (RLR) 是病毒感染的关键传感器，介导 I 型干扰素和其他基因的转录诱导，共同建立抗病毒宿主反应。最近的研究表明，病毒和宿主来源的 RNA 都可以触发 RLR 激活；如果 RLR 活性不受控制，这可能会导致有效的抗病毒反应，但也会导致免疫病理学。在这篇综述中，我们讨论了在病毒感染、恶性肿瘤和自身免疫性疾病的背景下，我们对 RLR 感知的 RNA 类型的理解的最新进展。我们进一步描述了 RLR 的活性如何受到宿主调控机制的控制，包括 RLR 相互作用蛋白、翻译后修饰和非编码 RNA。最后，我们讨论 RLR 领域的关键悬而未决的问题，包括如何将我们对 RLR 生物学的知识转化为新的疗法。

更新日期：2020-03-13

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11