Case-finding strategies for tuberculosis diagnosis rely on symptom screening, which is associated with poor sensitivity, resultant delays in diagnosis, increased patient morbidity, and ongoing transmission. There is need for a more sensitive, non-sputum-based triage test to exclude tuberculosis at the primary care level, and for mass screening in high-burden settings. Several blood transcriptional diagnostic signatures have been described; however, these were invariably discovered and validated in carefully selected case-control cohorts, inflating diagnostic accuracy. A crucial step in the development pathway is assessment of prospective diagnostic accuracy in real-world health-care settings.

中文翻译：

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用于结核病检测的血液转录特征。

结核病诊断的病例发现策略依赖于症状筛查，这与敏感性差、导致诊断延迟、患者发病率增加和持续传播有关。需要进行更敏感、不基于痰液的分诊检测，以在初级保健水平排除结核病，并在高负担环境中进行大规模筛查。已经描述了几种血液转录诊断特征；然而，这些都是在精心挑选的病例对照队列中发现和验证的，从而夸大了诊断的准确性。开发路径中的一个关键步骤是评估现实世界医疗保健环境中的前瞻性诊断准确性。