Abstract

The cytochrome P450s (CYPs) constitute a family of enzymes maintaining vital functions in the body and are mostly recognized for their significant role in detoxification. Of the CYP subfamilies, CYP3A, is one of the most active in the clearance of drugs and other xenobiotics. During the last decades, much focus has been on exploring different models for human CYP3A regulation, expression and activity. In that respect, the growing knowledge of the porcine CYP3As is of great interest. Although many aspects of porcine CYP3A regulation and activity are still unknown, the current literature provides a basic understanding of the porcine CYP3As that can be used e.g., when translating results from studies done in the porcine model into human settings. In this review, the current knowledge about porcine CYP3A expression, regulation, activity and metabolic significance are highlighted. Future research needs are also identified.

中文翻译：

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猪细胞色素P450 3A：表达和调控的当前状态。

摘要

细胞色素P450（CYP）构成维持体内重要功能的酶家族，并且因其在排毒中的重要作用而广为人知。在CYP家族中，CYP3A是清除药物和其他异源物质中最活跃的一种。在过去的几十年中，人们非常关注探索人类CYP3A调控，表达和活性的不同模型。在这方面，对猪CYP3A的日益了解引起了极大的兴趣。尽管尚不清楚猪CYP3A的调控和活性的许多方面，但当前文献提供了对可以使用的猪CYP3A的基本理解，例如，将猪模型中的研究结果转化为人类环境时可以使用。在本综述中，有关猪CYP3A表达，调控，活性和代谢意义突出。还确定了未来的研究需求。