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Ionic liquid-immobilized proline(s) organocatalyst-catalyzed one-pot multi-component Mannich reaction under solvent-free condition
Research on Chemical Intermediates ( IF 2.8 ) Pub Date : 2020-01-28 , DOI: 10.1007/s11164-020-04096-w
M. D. Prabhakara , Barnali Maiti

Abstract

A highly efficient clean and simple methodology has been established for the one-pot Mannich reaction using ionic liquid-immobilized proline(s) organocatalyst under solvent-free conditions. The three components comprising substituted acetophenones, substituted aromatic aldehydes and substituted aromatic amines underwent Mannich reactions in the presence of 7 mol% of ionic liquid-immobilized proline(s) organocatalyst to provide β-amino carbonyl compounds in 2–3 h at room temperature with excellent yields. This methodology provides several advantages such as mild reaction conditions, short reaction time, low catalyst loading percentage, multi-component approach, transition metal-free and solvent-free synthesis. The ionic liquid-immobilized proline(s) organocatalyst was recycled and reused five times without a significant loss of its catalytic activity.

Graphic Abstract



中文翻译:

无溶剂条件下离子液体固定化脯氨酸有机催化剂催化的一锅多组分曼尼希反应

摘要

对于无溶剂条件下使用离子液体固定的脯氨酸有机催化剂的单锅曼尼希反应,已经建立了一种高效,清洁,简便的方法。含有取代的苯乙酮,取代的芳族醛和取代的芳族胺的三种组分在7 mol%离子液体固定的脯氨酸有机催化剂存在下进行曼尼希反应,可在室温下2-3小时内提供β-氨基羰基化合物优异的产量。该方法具有许多优点,例如反应条件温和,反应时间短,催化剂负载率低,多组分方法,无过渡金属和无溶剂合成。

图形摘要

更新日期:2020-03-16
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