In this work, the boron-doped diamond electrode (BDDE) was used for the electrocatalytic oxidation of N-acetylcysteine (NAC), in the presence of lipoic acid (LipS₂), which works as an organic homogenous electrochemical catalyst. Cyclic voltammetry (CV), controlled-potential electrolysis, and differential pulse voltammetry (DPV) were performed in buffered aqueous solution at pH 7.0, in order to study the proposed system. Several analytical figures of merit were obtained for NAC, including a linear response range from 1 up to 100 μmol L⁻¹ and detection limit of 93 nmol L⁻¹. The method was successfully applied to the quantification of NAC in pharmaceutical preparations (capsules, syrup, and suspension), without matrix effects. The present study shows that the redox reaction between the studied thiolate and the electrogenerated cation radical of LipS₂, regenerating the original compound, on BDDE, is a promising analytical tool for quantifying NAC, in a relatively low oxidation potential, very simple, rapid, convenient, sensitive, and low-cost way.

在这项工作中，在作为有机均质电化学催化剂的硫辛酸（LipS ₂）存在下，掺硼金刚石电极（BDDE）用于N-乙酰半胱氨酸（NAC）的电催化氧化。为了研究该系统，在pH 7.0的缓冲水溶液中进行了循环伏安法（CV），控制电位电解法和差分脉冲伏安法（DPV）。获得了NAC的多项性能指标，包括线性响应范围为1至100μmolL ^-1和检出限为93 nmol L ^-1。该方法已成功应用于药物制剂（胶囊，糖浆和悬浮液）中NAC的定量分析，而没有基质效应。本研究表明，所研究的硫醇盐与LipS ₂电生成的阳离子自由基之间的氧化还原反应，在BDDE上再生原始化合物，是一种定量氧化NAC的有前途的分析工具，它具有相对较低的氧化电位，非常简单，快速，方便，敏感且低成本的方式。