With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able to hinder the progress of the disease and improve the therapeutic effectiveness. Since the discovery of pannexin (Panx), unremitting efforts on the study of this gap junction protein family member have revealed its role in participating in the expression of various physiopathological processes. Among them, the activation or inhibition of Panx channel has been shown to regulate the release of adenosine triphosphate (ATP) and other signals, which is very important for the onset and control of nervous system diseases including epilepsy. In this article, we summarize the factors influencing the regulation of Panx channel opening, hoping to find a way to interfere with the activation or inhibition of Panx channel that regulates the signal transduction of ATP and other factors so as to control the progression of epilepsy and improve the quality of life of epileptic patients who fail to respond to the existing medical therapies and those at risk of surgical treatment.

中文翻译：

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Pannexin-1通道调节癫痫中的ATP释放。

随着近几十年来对癫痫病研究的不断深入，该病的诊断和治疗取得了很大的进步。然而，由于混杂的症状和并发症以及复杂的内在发病机理，临床结果仍然不能令人满意。对癫痫发病机理的更好理解应该能够阻碍疾病的进展并提高治疗效果。自发现pannexin（Panx）以来，在研究该间隙连接蛋白家族成员方面的不懈努力表明其在参与各种生理病理过程表达中的作用。其中，已证明Panx通道的激活或抑制可调节三磷酸腺苷（ATP）和其他信号的释放，这对于包括癫痫在内的神经系统疾病的发作和控制非常重要。在本文中，我们总结了影响Panx通道开放的因素，希望找到一种方法来干扰Panx通道的激活或抑制，从而调节ATP的信号转导及其他因素，从而控制癫痫的发生和发展。改善了对现有药物治疗无效和有手术治疗风险的癫痫患者的生活质量。