The cis-[Ru(bpy)₂(Met)](PF₆)₂ complex, where Met = l-methionine and bpy = 2,2′-bipyridine, was prepared and fully characterized. This complex was subjected to blue and green light photolysis (453 and 505 nm, respectively) in aqueous solution, leading to the release of methionine and formation of the cis-[Ru(bpy)₂(H₂O)₂]²⁺ ion. This latter photoproduct was shown to subsequently interact with DNA, while DNA photocleavage was noticed. In agreement with these reactivities, this compound exhibited an exciting antibacterial action, particularly against Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, which was enhanced upon blue light irradiation. Altogether, these results showed that our strategy was successful in producing light-triggered DNA-binding agents with pharmacological potential and a likely blocking reagent for efficient peptide chemistry formation.

中文翻译：

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一种不寻常的双齿蛋氨酸钌（II）络合物：光解开孔和抗菌活性。

制备了顺式-[Ru（bpy）₂（Met）]（PF ₆）₂络合物，其中Met =  1-甲硫氨酸，bpy = 2,2'-联吡啶。在水溶液中对该络合物进行蓝光和绿光光解（分别为453和505 nm），导致蛋氨酸的释放并形成顺式-[Ru（bpy）₂（H ₂ O）₂ ] ²⁺离子。后者的光产物显示出随后可与DNA相互作用，而DNA发生了光裂解。与这些反应性一致，该化合物表现出令人兴奋的抗菌作用，尤其是针对革兰氏阳性细菌金黄色葡萄球菌和表皮葡萄球菌在蓝光照射下增强。总而言之，这些结果表明我们的策略成功地产生了具有药理学潜力的轻触发的DNA结合剂，并可能成为有效肽化学形成的封闭剂。