Purpose

This study (a) assessed quality of life (QoL) in a patient sample with severe mental illness in an integrated psychiatric care (IC) programme in selected regions in Germany, (b) compared QoL among diagnostic groups and (c) identified socio-demographic, psychiatric anamnestic and clinical characteristics associated with QoL.

Methods

This cross-sectional study included severely mentally ill outpatients with substantial impairments in social functioning. Separate dimensions of QoL were assessed with the World Health Organisation’s generic 26-item quality of life (WHOQOL-BREF) instrument. Descriptive analyses and analyses of variance (ANOVAs) were conducted for the overall sample as well as for diagnostic group.

Results

A total of 953 patients fully completed the WHOQOL-BREF questionnaire. QoL in this sample was lower than in the general population (mean 34.1; 95% confidence interval (CI) 32.8 to 35.5), with the lowest QoL in unipolar depression patients (mean 30.5; 95% CI 28.9 to 32.2) and the highest in dementia patients (mean 53.0; 95% CI 47.5 to 58.5). Main psychiatric diagnosis, living situation (alone, partner/relatives, assisted), number of disease episodes, source of income, age and clinical global impression (CGI) scores were identified as potential predictors of QoL, but explained only a small part of the variation.

Conclusion

Aspects of health care that increase QoL despite the presence of a mental disorder are essential for severely mentally ill patients, as complete freedom from the disorder cannot be expected. QoL as a patient-centred outcome should be used as only one component among the recovery measures evaluating treatment outcomes in mental health care.

中文翻译：

---

患有严重精神疾病的患者的生活质量：综合门诊医疗保健模式中的横断面调查。

目的

这项研究（a）在德国特定地区的综合精神病护理（IC）计划中评估了患有严重精神疾病的患者样本的生活质量（QoL），（b）比较了诊断组之间的QoL，以及（c）与QoL相关的人口统计学，精神病学记忆和临床特征。

方法

这项横断面研究包括重度精神病患者，社交功能严重受损。生活质量的不同维度通过世界卫生组织的通用26个项目的生活质量（WHOQOL-BREF）仪器进行了评估。对整个样本以及诊断组进行了描述性分析和方差分析（ANOVA）。

结果

共有953位患者完全填写了WHOQOL-BREF问卷。该样本的QoL低于一般人群（平均34.1; 95％置信区间（CI）32.8至35.5），单相抑郁患者的QoL最低（平均30.5; 95％CI 28.9至32.2），最高痴呆症患者（平均53.0; 95％CI 47.5至58.5）。主要精神病学诊断，生活状况（单独，伴侣/亲戚，辅助），疾病发作次数，收入来源，年龄和临床总体印象（CGI）得分被确定为QoL的潜在预测指标，但仅解释了一部分变异。

结论

尽管存在精神障碍，但仍会增加QoL的医疗保健方面对于重度精神疾病患者至关重要，因为无法期望完全摆脱该障碍。QoL以患者为中心的结果应仅用作评估精神卫生治疗结果的恢复措施中的一个组成部分。