Understanding of the impact of stem cell donation on donors' health-related quality of life (HRQOL) remains limited. A prospective observational study of eligible unrelated donors enrolled in the Japan Marrow Donor Program was conducted to compare HRQOL and adverse events (AEs) between peripheral blood stem cell (PBSC) and bone marrow (BM) donors. In total, 107 PBSC donors and 108 BM donors were enrolled. HRQOL scores for physical status were significantly lower in BM donors 1 week post-harvest (P < 0.001), but there were no significant differences between the two groups at baseline or 3 months post-harvest. PBSC donors were more likely to experience AEs before harvest (P < 0.001). However, at harvest, moderate-to-severe AEs were more common in BM donors (P = 0.001). After harvest, all grades of AEs were significantly higher in BM donors (P < 0.001). Among BM donors, a lower total physical score at baseline [odds ratio (OR) 1.21], female sex [OR 2.71], and young donors (OR 3.08) were risk factors for moderate-to-severe AEs at harvest, while among PBSC donors, only female sex (OR 4.86) was a risk factor. Our findings show better HRQOL during PBSC donation. These data help support decision-making by potential donors.

中文翻译：

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外周血干细胞供体和骨髓供体的健康相关生活质量：日本的一项前瞻性研究。

对干细胞捐赠对捐赠者健康相关生活质量（HRQOL）的影响的了解仍然有限。一项对参与日本捐精计划的合格无关捐献者的前瞻性观察研究旨在比较外周血干细胞（PBSC）和骨髓捐献者之间的HRQOL和不良事件（AE）。总共招募了107个PBSC供体和108个BM供体。收获后1周，BM供体的身体状况HRQOL评分显着降低（P <0.001），但两组在基线时或收获后3个月之间无显着差异。PBSC供体在收获前更有可能发生AE（P <0.001）。但是，在收获时，中度至重度不良事件在BM供体中更为常见（P = 0.001）。收获后 BM供体的所有级别的AE均显着更高（P <0.001）。在BM供体中，基线时的总身体得分较低[几率（OR）1.21]，女性[OR 2.71]和年轻供体（OR 3.08）是收获时中度至重度AE的危险因素，而在PBSC中捐助者中，只有女性（OR 4.86）是危险因素。我们的发现表明，在PBSC捐赠过程中，HRQOL更好。这些数据有助于支持潜在捐助者的决策。