In the Japan Marrow Donor Program (JMDP), autologous blood is collected from most unrelated bone marrow (BM) donors. We retrospectively evaluated 5772 donors who underwent BM harvest between 2010 and 2015 through the JMDP. Autologous blood was collected in 96.8% of the donors; the wastage rate was 0.6%. Allogeneic blood transfusion was not required. The mean hemoglobin (Hb) levels were 12.1 g/dL after the BM harvest (mean 891 mL) together with autologous blood transfusion (mean 596 mL). Propensity-score matching was used to adjust the backgrounds. Among donors with harvested BM of 100-400 mL, autologous blood transfusion had no impact on Hb levels or complications after BM harvest. Among donors with harvested BM of > 400 mL, more autologous blood transfusion followed by a bleeding volume of ≤ 100 mL did not confer clinical benefit to donors compared with less autologous blood transfusion followed by a bleeding volume of > 300 mL. The findings of the present study suggest that autologous blood transfusion to BM donors is excessive in terms of Hb changes and post-harvest outcomes.

中文翻译：

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自相关供者骨髓收获中自体输血的临床意义。

在日本骨髓捐献者计划（JMDP）中，从大多数无关的骨髓（BM）捐献者中收集自体血液。我们回顾性评估了2010年至2015年间通过JMDP进行BM收获的5772名捐助者。96.8％的献血者收集了自体血；浪费率为0.6％。不需要异体输血。BM收获后平均血红蛋白（Hb）水平为12.1 g / dL（平均891 mL），同时自体输血（平均596 mL）。倾向得分匹配用于调整背景。在收获的BM为100-400 mL的供体中，自体输血对BM收获后的Hb水平或并发症没有影响。在收获的BM> 400 mL的捐助者中，与之相比，自体输血少而后出血量大于300 mL的情况下，更多的自体输血后出血量≤100 mL的治疗对捐献者没有临床益处。本研究的发现表明，就血红蛋白变化和收获后结局而言，向BM供体的自体输血过多。